Vitamin D3, parathyroid hormones, and calcium levels in patients with hypothyroidism and chronic kidney disease and the relationship between them

Abstract

It is well known that there is interaction between thyroid hormones and renal function but this relationship still cause confusion and debate because there are aspects in it that are still mysterious until now. So this work aims to study the thyroid hormones and kidney’s enzymes levels in both chronic kidney disease (CKD) and hypothyroidism and the affect of these diseases on other physiological aspects such as parathyroid hormone (PTH), calcium Ca, and vitamin D3 (Vit D3) levels. Forty patients and 20 healthy subjects, aged 20-50 years of both ganders, were included in this study. These patients divided to tow groups (n=20). The first group has CKD, and the second group has hypothyroidism. Blood samples were collected from all subjects and centrifuged to separate the serums which were used to estimate the level of T4, T3, TSH, Vit D3, and PTH by Access 2 using a kits supplied by KARL KOLB, Germany; and Blood urea BU, serum creatinine (SCr), uric acid, and Ca by AU 480 (Biochemistry Device) using a kits supplied by KARL KOLB, Germany. TSH hormone levels increase significantly in the hypothyroidism group while T4 hormone level decrease significantly in both patients groups but there was no significantly different in T3 among these groups. SCr levels are significantly higher in CKD and hypothyroidism group while BU level was significantly higher in the CKD. However, there was no significant different in the Albumin and Uric acid levels among these groups. While the PTH level increase significantly and Ca level decrease significantly in the CKD patient group, vit D3 level was significant lower in both patient groups. We could conclude that CKD patients have an increased risk of hypothyroidism while hypothyroidism patients have an increased risk of CKD. In addition, Vit D3 decreases in both hypothyroidism and CKD patients while the elevated in PTH level and the reduction in Ca level were indicated only in CKD patients.

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