Use of topical administration of interleukin-1 receptor antagonist on equine cutaneous wound healing

Abstract

The present study was conducted on 16 local Arabian mares divided randomly into 4 groups, four for each. The aim was to evaluate the use of topical administration of IL-1Ra on equine cutaneous wound healing. Autologous interlukin-1 receptor antagonist (IL-Ra) were prepared. Under routine surgery complete square cutaneous wound 5x5mm2 were done in the back region of G1 and G3, and the neck region of G2 and G4. G2and G4 had no any treatment. The wounds of G1 and G2 treated topically with the extracted serum 1ml. daily for one week. By caliper the ribs of the square wounds were measured weekly for one month and recorded. Biopsies were taken for histopathological evaluation at 1,2,3, and 4 weeks. The results proved the superiority potential effect of IL-1Ra on wound healing of G1 than G2.

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