In recent years, for the prevention and treatment of acute gastrointestinal diseases (AGID) of newborn calves, many methods and schemes have been proposed using various drugs, both domestic and imported. At the same time, there are very few affordable, cheap, environmentally friendly drugs for the effective treatment of this pathology. One of such agents with a combined effect is a new effective way to treat calf dyspepsia - the combined use of an innovative drug - Iodpropionix, which is a product of biotechnological production (concentrated biomass of propionic acid bacteria P. freudenreichii subsp. Shermanii KM-186 in a living active form (1010-1011 CFU/cm3) (Khamagaeva and Badlueva 2007), containing 20 μg of iodine in 1 ml in combination with an immunostimulant - Stimadent. This article presents the results of scientific studies showing the effectiveness of the use of the innovative drug - Iodpropionix - with an immunostimulator - Stimadent - in the treatment of dyspepsia of newborn calves in a comparative aspect. It was established that the effectiveness of the treatment of newborn calves with dyspepsia using the innovative drug Iodpropionix with Stimadent was 20% higher than with Sulfa - 480. The use of Iodopropionix in combination with Stimadent significantly increased the concentration in the blood of the experimental group of calves on the 10th day of treatment: hemoglobin, red blood cells, total protein, total calcium, inorganic phosphorus, protein-bound iodine (PBI), and alkaline reserve, respectively, by 14.61; 14.12; 15.64; 7.14, 17.70; 50.35; and 11.50% compared with the control group. Drug treatment of calves of the experimental group with dyspepsia with innovative drug Iodopropionix in combination with an immunostimulant Stimadent increases their recovery rate, average daily gain in live weight and reduces the duration of the disease by 20.0; 20% and 2 times, respectively, compared with calves of the control group.


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