The main problem for denture users is denture stomatitis caused by Candida albicans which in a pathogenic state can release endotoxins that damage the oral mucosa. Meniran plant contains antifungal compounds that can be used as an alternative mouthwash for denture users. This study aims to determine the level of toxicity of Meniran plant extracts as mouthwash ingredients for dentures towards gingival fibroblast cell cultures. This study is an experimental research. There is a fibroblast cell control group and fibroblast cell treatment group that was added with Meniran plant extracts. All samples were incubated in the media for 24 hours. The samples were then given MTT material and incubated again for 4 hours. Cell culture on the plate was then read by ELISA reader. The results were analyzed using Kruskal-Wallis and HSD-Tukey. The results showed that there were significant differences between the cell groups and the treatment groups. The treatment results showed the percentage of living cells in the treatment group giving Meniran plants of 40%, 20%, 10%, and 5% respectively, which were 61.1%, 67.3%, 73.6%, 78.1%.  Meniran plant extract is not toxic and can reduce the excess amount of Candida albicans.

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