This study was conducted for the period from 15/12/2019 to 30/01/2020 in the laboratories of Samarra General Hospital and outpatient clinics, as 40 samples were collected (20) a sample infected with rheumatoid arthritis diagnosed by doctors and (20) healthy samples as a control group. Their ages ranged between (35-80) years. As 6 ml of venous blood was withdrawn and (4) ml was placed in plastic tubes and free from anticoagulant for the purpose of Determination concentrations (Prolidase, MDA, Ceroplasmin) and (2) ml to Erythrocyte Sedimentation rate ESR, and the results were statistically analyzed by testing the variance at a significant level P≤ 0.05. The results showed a significant increase in the effectiveness of prolidase enzyme in patients with rheumatoid arthritis compared to the control group at a significant level P≤ 0.05 and an increase in the concentration of Ceroplasmin, ESR and malondialdehyde in the patients group compared to the control group P≤ 0.05

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