Background: In terms of its clinical characteristics, nasopharyngeal carcinoma (NPC) is easy to invade and metastasize. Therefore, it can cause locoregional recurrence and distant metastasis.The Prediction of the current NPC prognosis remains generally based on clinical stage assessments. In fact, patients with the same stage often get different therapeutic results. Purposes: This research aims to analyze the correlation between VEGF expressions and the enlarged cervical lymph nodes in NPC. Methods: This research utilized an observational analytic with the cross sectional approach. The samples employed 18 NPC patients with cervical lymph nodes from the criteria of N0 N1, N2, and N3, of type III WHO histopathology (undifferentiated carcinoma) who have never received any therapy. The data were analyzed using the Mann-Whitney U-test to determine the correlation between the increased VEGF expressions and the enlarged cervical lymph nodes with significance level (a) = 0.05. Result: From all samples, 83.33% of weak expressions were found, while moderate expressions amounted to 16.67%. The result of the Mann Whitney U-test indicated a p-value of 0.058. This fact suggested that the correlation between the increased of VEGF expressions and N had no significant differences. Conclusion: There are no correlations between VEGF expressions and the enlarged cervical lymph nodes.

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