In Iraqi patients with Oral Sequamou cell cancer, little is understood about the expression of Mmp7 and Fox protein. Fox ‘s positive expression was significantly associated with the location (p=0.016) and clinical appearance. Positive expression of Fox has been noted in all cases of oral sequamoucell carcinomacases that represent their essential function in inflammation, indicating that it can be used as inhibitors for head and neck malignancies to improve anti-inflammation therapies.Oral sequamou cell carcinoma mucocutaneous uncertain cause (of a disease) with an ability (to hold or do something) for harmful change is considered to be oral oral sequamous cell cancer. In Iraqi patients with Oral Sequamou cell cancer, little is understood about the expression of Mmp7 and Fox protein. The current research was aimed at assessing the expression of Mmp7 and Fox protein in the portion of Oral oral sequamou cell carcinomausing immunohistochemical teqnique in Iraq. Parts of 22 embedded formalin-fixed paraffin blocks of Oral oral sequamou cell carcinomawere immunostained to determine the expression of Mmp7 and Fox. The term Mmp7 and Fox in both oral sequamou cell carcinomacases was positive (100 percent). Fox ‘s positive expression was significantly associated with the location (p=0.016) and clinical appearance (p-value=0.003). The positive expression of Mmp7 was substantially statically associated with the location of tumors (p-value = 0.002). There was a non-significant association between Mmp7 and Fox, on the other hand (p-value=0.021). The positive expression of Mmp7 And Fox has been noted in all cases of oral sequamou cell carcinomacases that represent their essential function in inflammation, indicating that it can be used as inhibitors for head and neck malignancies to improve anti-inflammation therapies.

• Abcam (2013). ab80436 – EXPOSE Mouse and Rabbit Specific HRP/DAB Detection IHC Kit Version: 2 last updated: 22.
• Abdulbaqi, N. J. & Dheeb, B. I. & Irshad, R. (2018). Expression of Biotransformation and Antioxidant Genes in the Liver of Albino Mice after Exposure to Aflatoxin B1 and an Antioxidant Sourced from Turmeric (Curcuma longa). Jordan Journal of Biological Sciences. 11 (2) 89 – 93.
• Al-Qazzaz HH. (2012)..Immunohistochemical Expression Transforming Growth Factor-beta (TGF-β) in relation to invasion potential evaluated by Matrix Metalloproteinase-2 (MMP-2) in Oral Squamous Cell Carcinoma. A master thesis in Oral Pathology, Department of Oral Diagnosis, College of Dentistry, University of Baghdad.
• Al-Tekreeti, A. R., Al-Halbosiy, M. M. F., Dheeb, B. I., Hashim, A. J. & Al-Zuhairi, A. F. H. (2017). Molecular identification of clinical Candida isolates by simple and randomly amplified polymorphic DNA-PCR. Arab J Sci Eng. DOI 10.1007/s13369-017-2762-1.
• Bander, K. I., Mohammed, S. H., Thalij, K. M. & Dheeb, B.I. (2015). Survey Study of theAllergic Fungi in Kirkuk Area and Use Molecular Detection for Identification. I J S: B A R. 19 (1):383-397.
• Bandyopadhyay,B.;Fan, J.; Guan, S.; Li, Y.;Chen,M.; Woodley, D.T. & Li, W. (2006). ”A “traffic control” role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing”. J Cell Biol. 172 (7):1093-105.
• Dahham, MT, Omar, AF, Dheeb BI. (2019). Synergistic effect of tea tree oil on fungi causing vaginal thrush in pregnant women. Journal of Biotechnology Research Center 13 (2)35-44.
• Devore, C.H. (2010). Plaque score changes based primarily on patients performance at specific time intervals. Journal of Periodontology 61,343-346.
• Dheeb BI, Al-dujayli SMA, Ibrahim IM, Abbas QA. (2019). Study the Antifungal Activity of ZnS:Mn Nanoparticles Against Some Isolated Pathogenic Fungi. Journal of Physics: Conference Series, 1178, 46–52.
• Dheeb, BI, (2015). Antifungal Activity of Alkaloids and Phenols Compounds extracted from black pepper Piper nigrum against some pathogenic fungi Jornal of B R. 9 (2), 46-54
• Dheeb, B. I., Al-Mashhadani, I. I., Ismail, E. N., Majeed, S. M., & Majeed, D. M. (2014).AStudy of the Expression of Aflatoxin B1 Regulatory Gene in Clinical and Environmental Aspergillusflavus using Real-time PCRI J S: B A R, 17 (1), 417-427.
• Dheeb, B. I., Al-Mudallal, N. H., Salman, Z. A. and Ali, M. (2015). The Inhibitory Effects of Human, Camel and Cow’s Milk against Some Pathogenic Fungi in Iraq. Jordan Journal of Biological Sciences. 8 (2) 89 – 93.
• El-Hilali, F., El-Hilali, H., Dheeb, B. I., Traore, B. M., Messouak, M., Mazouz, H., Moumni, M., Belgacem, F. B. M. & El-Mowafy, A. M. (2016). Blood Transfusion Utility DuringCardiopulmonary Bypass and Correlation with Key-Biochemical Laboratory Findings: A New Approach to Identify Preventive and Risk Factors (1-Year Practice at University Hospital Hassan-II of Fez). Biochem Anal Biochem. 5:3 DOI: 10.4172/2161-1009.1000290.
• Hammadi, SY., Hussein, AS., Majeed, DM., Dheeb, BI., EN (2019). Ismail. RAPD and ISSR analyses of Saccharomyces cerevisiae isolates from different sources Jornal of BRC 12 (2), 40-50
• Hamoody, AHM., Abood, JN., Dheeb, BI., (2020). The synergistic effect of fungus filter Aspergillus terreus and aqueous extract of Fucus vesiculosus on some growth characteristics of the ocimum basilicum and its content of heocimumbasilicum and itscontentof active substances EurasiaJBiosci14,161-166 14, 161-166
• Harris L, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S, et al. (2007).American Society of Clinical Oncology update of recommendation for the use of tumor markers in breast cancer. J Clin Oncol 2007;25:5287–312. Abstract/FREE Full TextGoogle Scholar.
• Henry L, Hayes DF. (2006).Uses and abuses of tumor markers in the diagnosis, monitoring and treatment of primary and metastatic breast cancer. Oncologist 11:541–52. Abstract/FREE Full TextGoogle Scholar.
• Husain, AS., Thalij, KM., Dheeb. BI., (2014). Effects of interaction between Aflatoxins (AFs) and functional materials FM in the hematological, biochemical parameters and enzyme activity in Rats. Egyptian Academic Journal of Biological Sciences, B. Zoology. 6 (2), 17-2.
• Hussain AF, Sulaiman GM, Dheeb BI, Hashim AJ. (2018).Histopathological changes and expression of transforming growth factor beta (TGF-β3) in mice exposed to gliotoxin. Journal of K S U – Science. 27, 193–197.12.
• Hussain, A. F., Sulaiman, G. M., Dheeb, B. I., Hashim, A. J. (2017). and Seddiq, S. H.. Improving conditions for gliotoxin production by local isolates of Aspergillus fumigatus. Journal of biotechnology research center. 11 (2):14-24.
• Hussain, A. F., Sulaiman, G. M., Dheeb, B. I., Hashim, A. J. (2017).). Immunohistochemical study of Tumor Necrosis Factor -alpha (TNF- α) expression in lung, liver, and spleen during aspergillosis infection. BMC genomics. 15 (2), 71.
• Hussain, AF, Sulaiman, GM, Dheeb, BI, Hashim, AJ, Alrahman, ESA (2020). Histopathological changes and expression of transforming growth factor beta (TGF-β3) in mice exposed to gliotoxin
• Hussain,H.T. (2010)Isolation Of Blastomyces dermatitidis histopathological and immunologically in Baghdad. A Thesis Submitted to College of Medicine - Al-Nahrain University.
• Hussein, HS, Dheeb BI, Hamada,TA. (2019).Studying the candida resistance and sensitivity for some antifungals. Journal of Biotechnology Research Center 13 (2)25-34.
• Ibrahim, I. M., Iftikhar, M., Ali, I. M., Dheeb, B. I., Abbas, Q. A., Ramizy, A., Eisa, M. H. and Aljameel, A. I. (2017).. Antifungal activity of wide band gap Thioglycolic acid capped ZnS:Mn semiconductor nanoparticles against some pathogenic fungi.Materials Science and Engineering C 73:665–669.
• Journal of K S U – Science 27, 193–197.
• Kubiczkova, L.; Sedlarikova, L.; Hajek, R.; & Sevcikova,S. (2012).TGF-β – an excellent servant but a bad master, Journal of Translational Medicine, 10:183.
• Loeffler, I. & Wolf, G. (2014).Transforming growth factor-β and the progression of renal disease Nephrol Dial Transplant, 29: i37–i45.
• Marcotte H, Lavoie MC. (2008). Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev 62: 71-109.
• Marsh PD. (2006).Host defenses and microbial homeostasis: role of microbial interactions. J Dent Res 68: 1567-1575.
• Massague, J. (1998). TGF-beta signal transduction. Annu Rev Biochem, 67: 753-791.
• Minah GE, Rednor JL, Peterson DE, Overholser CD, Depaola LG, Suzuki JB. (2011). Oral succession of gram-negative bacilli in myelosuppressed cancer patients. J Clin Mic-robiol 24: 210-213.
• Mohammed AA. (2008). The expression of CD34 and podoplanin as biological markers of angiogenesis and lymphangiogensis in oral and coetaneous squamous cell carcinoma (a comparative study). Amaster thesis in Oral Pathology, Department of Oral Diagnosis, College of Dentistry, University of Baghdad.
• Neville B.W, Damm DD, Allen CM. (2009). oral and maxillofacial pathology. Philadelphia: Saunders.
• Nouri, M. A., Al-Halbosiy, M. M. F., Dheeb, B. I. & Hashim, A. J. (2015).Cytotoxicity and genotoxicity of gliotoxin on human lymphocytes in vitro. Journal of K S U – Science. 27, 193–197.
• Nur ÖZDABAK* et al. (2012). Identification of aerobic bacterial flora in saliva of subject who apply to the faculty of dentistry in Ataturk University by using microbial identification system. J Dent Fac Atatürk Uni.
• Rassin, N. K., Nemat J. A, Dheeb, B. I. (2015). Molecular Identification of Aspergillus fumigatus Using ISSR and RAPD Markers. Iraqi Journal of Science. 56 (4A), 2788-2797.
• Smith DJ, Taubman MA, Ebersole JL. (2007). Ontogeny and senescence of salivary immunity. J Dent Res 6: 451-456.
• Thylstrup A, Fejerkov O. (2004). Textbook of Clinical Cariology. 2 ed.Copenhagen; Munsgaard: p. 5-50.
• Willcox MDP, Drucker DB, Green RM. (2009).In vivo dental plaque-forming ability and cariogenicity of the bacterium Streptococcus bovis in gnotobiotic rats. Arch Oral Biol 35:163-166.
• Xavier, M.B.; Libonati, R.M.F.; Unger,D.; Oliveira,C.; Corbett,C.E.P.; de Brito,A,C.; Quaresma, J.A.S. (2008).Macrophage and TGF-β Immunohistochemical expression in Jorge Lobo’s disease Human Pathology 39, 269–274.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.