The considerable evidence between latent toxoplasma infection with testosterone and total antioxidant among infertile women


Toxoplasma gondii an intracellular parasite that cause toxoplasmosis. Toxoplasma infection it’s well known to induce various physiological, hormonal and behavioral changes in humans and animals. In current study, 147 infertile women were divided into three groups, primary, secondary infertility and aborted woman (sub-infertility). Twenty healthy volunteer women served as controls. Enzyme linked immunofluorescence assay was used to confirm anti-Toxoplasma IgG antibodies. Whereas, Testosterone concentration were measured by ELISA technique. We investigated the testosterone and total antioxidant capacity (TAC) in free and infected (Toxoplasma gondii) infertile women, to provide clinical scenario that may be adopted as one causes of primary, secondary infertility and sub infertility. Although, there are no significant variation in Testosterone levels between infertility women groups, but according normal, hypo and hyper range, testosterone were increased significantly just in toxoplasmosis women(p-value=0.04), whereas no significant variation are seen in other infertile groups. Testosterone statistically decreased in primary infertile women. In additions, serological analysis confirm that 28 (19%) enrolled women were seropositive for Toxoplasma gondii. Toxoplasmosis have a significant impact on Total antioxidant capacity especially in secondary infertility and sub-infertility. In addition no significant variations were reached in TAC and Testosterone as correlated with intensity of parasites (anti-IgG antibodies) .interestingly the testosterone hyper concentration are found in secondary infertile women(p-value=0.01, 29%) and in opposite direction percentage of hypo-testosterone is increased significantly in primary infertility women . In conclusion this study suggested a considerable evidence of hypothesis that consider Toxoplasmosis is a one of a risk factor for increase the level of Testosterone and increasing the chance of infertility in women especially according Hypo-Hyper values. Also based our data that supplementations of TAC is recommended for women who had primary and secondary infertility to enhance reproductive outcome.


  • Al Mulla A, Fazari AB, Elkhouly M, Moghaddam N (2018) Role of antioxidants in female fertility. Open Journal of Obstetrics and Gynecology 08(02): 85-91.
  • Al-Fartusie FS (2012) Study of some trace elements and antioxidant vitamins in sera of Iraqi women with toxoplasmosis. Al-Mustansiriyah Journal of Science 23(3): 199-206.
  • Apak R, Güçlü K, Özyürek M, Çelik SE (2008) Mechanism of antioxidant capacity assays and the CUPRAC (cupric ion reducing antioxidant capacity) assay. Microchimica Acta 160(4).
  • Bahrami S, et al. (2016) Blood Levels of Oxidant/Antioxidant Parameters in Rats Infected with Toxoplasma Gondii. Oxidative Medicine and Cellular Longevity 2016.
  • Bamba S, Cissé M, Sangaré I, Zida A, Ouattara S, Guiguemdé RT (2017) Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women from Bobo Dioulasso, Burkina Faso. BMC Infectious Diseases 17(1): 1-6.
  • Bird BM, Samuele Z (2019) Encyclopedia of Evolutionary Psychological Science. Encyclopedia of Evolutionary Psychological Science (January).
  • Carré JM, Archer J (2018) Testosterone and human behavior: The role of individual and contextual variables. Current opinion in psychology, 19, 149-153.
  • Dubey JP (2008) The History of Toxoplasma Gondii - The First 100 Years. Journal of Eukaryotic Microbiology 55(6): 467-75.
  • El-Shahaby OA, El-Zayat M, Abd El-Fattah G, El-Hefny MM (2019) Evaluation of the biological activity of Capparis spinosa var. aegyptiaca essential oils and fatty constituents as Anticipated Antioxidant and Antimicrobial Agents. Progress in Chemical and Biochemical Research 2(4): 211-221.
  • Eslamirad Z, et al (2013) Effects of Toxoplasma Gondii Infection in Level of Serum Testosterone in Males with Chronic Toxoplasmosis. Iranian Journal of Parasitology 8(4): 622-26.
  • Flegr J (2016). Host Manipulation by Toxoplasma Gondii. Encyclopedia of Parasitology (420): 1291-96.
  • Fletcher QE, Selman C, Boutin S, McAdam AG, Woods SB, Seo AY, ... Humphries MM (2013) Oxidative damage increases with reproductive energy expenditure and is reduced by food‐supplementation. Evolution 67(5): 1527-1536.
  • Galván-Ramírez MDLL, Gutiérrez-Maldonado AF, Verduzco-Grijalva F, Jiménez JMD (2014) The role of hormones on Toxoplasma gondii infection: a systematic review. Frontiers in microbiology 5: 503.
  • Innes EA (2010) A Brief History and Overview of Toxoplasma Gondii. Zoonoses and Public Health 57(1): 1-7.
  • Nirmala GS, Muruganandam L (2019) Hydrodynamics in a Liquid Solid Circulating Fluidized Bed-A Review. Journal of Chemical Reviews 1(2. pp. 78-170): 114-129.
  • Razumovskaya MI, Larionova AA, Zaitseva NA, Petrina OA, Vinogradova MV, Nagay NG, Takhumova OV (2019) Models of Integrated Interactions Organization in the Field of Environmental Education. Journal of Environmental Treatment Techniques 7(4): 576-580.
  • Schieber M, Chandel NS (2012) Ros function in redox signaling 100(2): 130-134.
  • Shirbazou S, Abasian L, TALEBI MF (2011) Effects of Toxoplasma gondii infection on plasma testosterone and cortisol level and stress index on patients referred to Sina hospital, Tehran. Jundishapur Journal of Microbiology 4(3): 167-74.
  • Sugden K, Moffitt TE, Pinto L, Poulton R, Williams BS, Caspi A (2016) Is Toxoplasma gondii infection related to brain and behavior impairments in humans? Evidence from a population-representative birth cohort. PLoS One 11(2): 1-14.
  • Tan BL, Norhaizan ME, Liew WPP, Rahman HS (2018) Antioxidant and oxidative stress: A mutual interplay in age-related diseases. Frontiers in Pharmacology 9(OCT): 1-28.
  • Tedford E, McConkey G (2017) Neurophysiological changes induced by chronic Toxoplasma gondii infection. Pathogens 6(2): 19.
  • Vyas A (2015) Mechanisms of host behavioral change in Toxoplasma gondii rodent association. PLoS pathogens 11(7): 1-6.
  • Zouei N, Shojaee S, Mohebali M, Keshavarz H (2018) The association of latent toxoplasmosis and level of serum testosterone in humans. BMC research notes 11(1): 365.


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