The current investigation was accompanied to assess the antibacterial efficacy of secondary metabolites compounds, such as: phenolic, terpenoids, and alkaloids extracted from leaves of Chinaberry tree (Melia azedarach L., Family: Meliaceae) counter to pathogenic microorganisms isolated from burns and gingivitis cases. by using agar well diffusion method. The aimed of this investigation was to assess the antibacterial efficacy of Phenolic, Terpenoids, and Alkaloids extracted from leaves of Chinaberry tree (Melia azedarach L.) against some pathogenic microorganisms isolated from burns and gingivitis cases. The data collected from the study revealed that, secondary metabolites compounds, such as: phenolic, terpenoids, and alkaloids extracted from leaves of Chinaberry tree had a range of antibacterial efficacy against pathogenic microorganisms isolated from burns and gingivitis cases. Streptococcus mitis and Staphylococcus aureus were exhibited fully unaffected to phenolic and terpenoids secondary metabolites extracted from leaves of Chinaberry tree (Melia azedarach L.). Escherichia coli were fully resistant to terpenoids compounds. Staphylococcus aureus were fully resistant to alkaloids compounds. In conclusion, secondary metabolites compounds extracted leaves of Chinaberry tree (Melia azedarach L.) considered a good source for make drugs against microorganisms isolated from burns and gingivitis cases especially alkaloids compounds.

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