Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2019 - Volume 13 Issue 1, pp. 517-522
  • Published Online: 12 May 2019
  • Article Views: 118 | Article Download: 70
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Kadhim NQ, Al-faraji SMH, Maher FT. Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients. Eurasia J Biosci. 2019;13(1), 517-522.

APA 6th edition
In-text citation: (Kadhim et al., 2019)
Reference: Kadhim, N. Q., Al-faraji, S. M. H., & Maher, F. T. (2019). Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients. Eurasian Journal of Biosciences, 13(1), 517-522.

Chicago
In-text citation: (Kadhim et al., 2019)
Reference: Kadhim, Nagham Q., Saif M. H. Al-faraji, and Firas T. Maher. "Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients". Eurasian Journal of Biosciences 2019 13 no. 1 (2019): 517-522.

Harvard
In-text citation: (Kadhim et al., 2019)
Reference: Kadhim, N. Q., Al-faraji, S. M. H., and Maher, F. T. (2019). Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients. Eurasian Journal of Biosciences, 13(1), pp. 517-522.

MLA
In-text citation: (Kadhim et al., 2019)
Reference: Kadhim, Nagham Q. et al. "Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients". Eurasian Journal of Biosciences, vol. 13, no. 1, 2019, pp. 517-522.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Kadhim NQ, Al-faraji SMH, Maher FT. Study of topoisomerase I (Topo I) level and some biochemical parameters in diabetic patients. Eurasia J Biosci. 2019;13(1):517-22.

Abstract

This study was done to determine level of Topoisomerase I and other biochemical parameters such as (Glucose, HbA1c, Insulin, C-Peptide, Cholesterol, Triglyceride, very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) in Diabetic patient. The study included (70) patients of both sexes with diabetes for both types (type 1 and type 2 diabetes mellitus) at age (27-79) year, and included (30) apparently healthy persons of both sexes as a control groups. The Results showed that there was a highly significant decrease (p≤0.01) in the level of Topoisomerase I in Diabetic patients compared with control group, no significant differences between both sexes and age groups studied and there were no significant differences in enzyme levels concerning mass body index (BMI) between patients and people with history of disease and without history of disease and smoking and non-smoking. Results also showed that there are a highly significant increase (p≤0.001) in the levels of glucose and HbA1c in patients group compared to control group and significant increase in insulin levels in type2 diabetic patients compared with control group, and a significant decrease in the levels of insulin in type1 diabetic patients compared with control group and a significant increase in C-peptide level in type 2 diabetic patients compared with control group while there was a significant decrease in type 1 diabetic patients compared with control group. There was a significant increase (p≤0.01) in cholesterol, triglyceride and VLDL levels in patients groups compared with control group, and no significant difference in HDL and LDL level.

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