Study of relationship between gout and infection with various kinds of renal stones in some biochemical variables
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 2, pp. 3847-3854
  • Published Online: 30 Sep 2020
  • Open Access Full Text (PDF)

Abstract

The current study aimed to investigate the relationship between Biochemical variables which are considered an indicator to kidneys function with uric acid concentration in patients with gout and various kinds of renal stones. This study was included 76 patients (42 males & 34 females) infected in gout and various kinds of renal stones, whose ages ranged (15-75) years, attending to Al-Salam Teaching Hospital and the special laboratories in Mosul city, the patients whose cases were diagnosed by the specialist physicians. Moreover, 50 healthy of both sexes with the same ages of patients were used a control for comparison. The results showed a significant increase in concentration of each of uric acid, urea, and creatinine, associated with a significant decrease in conc. of each of the total protein, albumin, and calcium but showed non-significant decrease in conc. of globulin in compared with control. The results also showed existing of a strong (+) relationship between conc. of uric acid and conc. of each one of urea and creatinine in the male patients, but that relationship was found strong (+) between conc. of uric acid, and conc. of each one of total protein, and albumin was found with the female patients. While, rest of the studied Biochemical variables showed no relationship between them and uric acid. In this study, 90 stones were collected from those patients after surgical operations, or after dropping of the stone with the urine involuntarily, so the results showed that the high ratio of the infection with pure calcium oxalate stones at 23.3%, stone of pure uric acid at % 17.9, cystine stones at 15.6%, stones mixed with each of calcium oxalate and uric acid, stones mixed with pure calcium  and calcium oxalate at the ratio of 10%, then the ratio of the stones composed of pure calcium reached 6.7%. We concluded that infection with gout and increasing conc. of uric acid led to infect in uric acid stones and other kinds of stones indicating to existing of metabolic dysfunction in the kidneys and urinary system.

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