Retrospective evaluation of hyperferritinemia and iron overload in patients with myelodysplastic syndrome


Introduction: The myelodysplastic syndromes (MDS) are a group of myeloid clonal disorders characterized by morphologic features, including hyper cellular bone marrow, unilineage or multilineage dysplasia and peripheral blood cytopenic. Anemia is the most commonly diagnosed cytopenic symptom in MDS patients. Regular red blood cell (RBC) transfusion is the often needed for the patients’ symptomatic anemia. Transfusion-dependent patient’s undergone tissue iron overload that may frequently be a prominent clinical feature. The purpose of this study was to determine the serum ferritin and iron levels in MDS patients and evaluation the outcome of the treatments received. Methods: In a retrospective study, the clinical and laboratory data were obtained of all patients with MDS referred to the clinic of Namazi hospital in Shiraz during 2017-2018 and analyzed by SPSS software. Results: Of 76 patients who entered the study 48 (62.66%) were males with a mean age of 68.48 ± 9.33 years and 28 (37.34%) were women with a mean age of 70.42 ± 10.97 years. The mean of ferritin serum level among all patients was 601.13 ± 828.29 mg / l which 16 men and 6 women had > 500 mg / l ferritin concentration, and a direct and significant correlation found between male and serum ferritin level. 17.33% of patients received iron chelator. In addition 15 (19.7%) and 6 (8.00%) of patients intake erythropoietin alone or with GM-SCF growth factor, respectively. Conclusion: Considering the relatively low number of studies are employed the hyperferritinemia in MDS patients, the obtained data define the hyperferritinemia incidence in MDS depended transfusion and serum ferritin higher than 1000 mg/dl can help to good prognosis for patient survival.


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