Potention of L-carnitine supplementation on changes in ejection fraction and left ventricular dimension in case of dilatative cardiomyopathy in children

Abstract

Background: Cardiomyopathy is a rare cardiac muscle disease with poor prognosis and high mortality. The main goal of dilated cardiomyopathy therapy is to restore and maximize cardiac function, but to date no medication has met these criteria. The use of oral L-carnitine as a dilated cardiomyopathy therapy has a potency to gives good results in restore and maximize cardiac function. Purpose: Knowing the effect of L-carnitine supplementation in children with cardiomyopathy on ejection fraction and left ventricular dimensions. Method: Experimental studies with randomized control trial design were conducted for one year, to determine the effect of L-carnitine in the experiment by performing twice the ejection fraction measurements and left ventricular dimensions performed before and after the administration of L-carnitine for 1 month. This research does not use blind method. Sampling was done randomly with comparison control. Different test was conducted with Saphiro-Wilk followed by T-test. Result: Fourteen samples were analyzed. In the treatment group, an increase in ejection fraction (p = 0.033), decreased left ventricular systolic phase end dimension (p = 0.043) and at the end of diastolic phase (p = 0.170). There was a significant difference in the increase of ejection fraction between treatment group and control group (p = 0,035), but no significant difference was found between treatment group and control group of final phase of systole (p = 0,228) and final phase of diastol (p = 0,704). Conclusion: L-carnitine supplementation in children with dilatative cardiomyopathy can increase ejection fraction, but not decrease the left ventricular dimension.

References

  • Abd, A. M. N. E. D. (2006). Therapeutic Evaluation of L-Carnitine in Egyptian Children with Dilated Cardiomyopathy” Alyaa Amal Kotby,”Gamal Abd El Nasser Yamamah,” Abeer M. Nour El Din Abd El Baky,” Ghada Mahmoud El Kassas and “Amal Zaghloul Abd Elhalim. J. Med. Sci, 6(5), 800-805.
  • Abdullsattar Saad, I. (2007). Idiopathic dilated cardiomyopathy in children; Natural history and predictors of prognosis. Libyan Journal of Medicine, 2(3), 129-134.
  • Ferrari, R., Merli, E., Cicchitelli, G., Mele, D., Fucili, A., & Ceconi, C. (2004). Therapeutic effects of l‐carnitine and propionyl‐l‐carnitine on cardiovascular diseases: A review. Annals of the New York Academy of Sciences, 1033(1), 79-91
  • Ferrari, R., Merli, E., Cicchitelli, G., Mele, D., Fucili, A., & Ceconi, C. (2004). Therapeutic effects of l‐carnitine and propionyl‐l‐carnitine on cardiovascular diseases: A review. Annals of the New York Academy of Sciences, 1033(1), 79-91.
  • Helton, E., Darragh, R., Francis, P., Fricker, F. J., Jue, K., Koch, G.,... & Winter, S. C. (2000). Metabolic aspects of myocardial disease and a role forl-carnitine in the treatment of childhood cardiomyopathy. Pediatrics, 105(6), 1260-1270.
  • Kaski, J. P., Syrris, P. M., Shaw, A. C., Esteban, M. T. T., Mckenna, W. J., & Elliott, P. M. (2010). Mutations in the RAS/MAPK signalling pathway cause idiopathic hypertrophic cardiomyopathy in pre-adolescent children. OXFORD UNIV PRESS.
  • Laswati, H., Sugiarto, D., Poerwandari, D., Pangkahila, J. A., & Kimura, H. (2018). Low-intensity exercise with blood flow restriction increases muscle strength without altering hsCRP and fibrinogen levels in healthy subjects. Chin J Physiol, 61(3), 188-195.
  • Lipshultz, S. E., Sleeper, L. A., Towbin, J. A., Lowe, A. M., Orav, E. J., Cox, G. F.,... & Colan, S. D. (2003). The incidence of pediatric cardiomyopathy in two regions of the United States. New England Journal of Medicine, 348(17), 1647-1655.
  • Lukiswanto, Ba. S., Wiwik misaco yuniarti YYM (2017). Effects of hyperbaric therapy on liver morphofunctional of rabbits (Oryctolagus cuniculus) after hind limb ischemia-reperfusion injury. Vet World.;10(11):1337–42.
  • Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M.,... & Lenzi, A. (2007). Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. european urology, 52(6), 1768-1776.
  • Putri, A. P. S., & Hidajah, A. C. (2019). Indicator of Dyslipidemia for Ischemic Stroke in Elderly with Hypertension. Indian Journal of Public Health Research & Development, 10(3), 642-648.
  • Rong, Sh.L, Wang, Z.K, Zhou BL, X. D (2019). Efficacy and safety of stem cell therapy in patients with dilated cardiomyopathy: a systematic appraisal and meta-analysis. J Transl Med. 17(1).
  • Tilahun, G., Mekbib, F., Fikre, A., & Eshete, M. (2015). Genotype X Environment Interaction and Stability Analysis for Yield and Yield Related Traits of Desi-Type Chickpea (Cicer Arietinum L.) In Ethiopia. Current Research in Agricultural Sciences, 2(3), 100-113.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.