Potentials of tranexamic acid injection to reduce bleeding in patients of total knee replacement procedure

Abstract

Background: The high number of patients with knee osteoarthritis causes an increasingly frequent arthroplasty. This surgical procedure of Total Knee Replacement poses a risk of massive bleeding, which can affect albumin levels and cause intra-compartmental pressure on the nerves. Objective: This study aims to determine the effect of tranexamic acid injection on total blood loss, the degree of pain, and the need for blood transfusions after surgery in patients undergoing the procedure for Total Knee Replacement. Method: The study was an experimental research using primary data from laboratory examination obtained before and after surgery in 64 patients of Total Knee Replacement surgery in the ER operating theater of Dr. Soetomo Regional Public Hospital, Surabaya. Result: In the group receiving tranexamic acid, the group with 32 people (100%) reported a low postoperative VAS score, and did not require blood and albumin transfusions. In the group not receiving tranexamic acid, 32 people (100%) had a moderate postoperative VAS score, where four people (12.5%) required blood transfusions, and three people (9.4%) required albumin transfusions. Conclusion: The administration of tranexamic acid reduce total blood loss, the degree of pain, and reduce the need for blood transfusions after total knee replacement surgery.

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