The emergence and spread of microbial drug resistance and lack of developing new antibacterial bacteria are a growing problem in multi-drug - resistant bacteria, Phytochemical compounds and silver Nanoparticles (NPs) synthesis has been of great interest because of their potential biomedical applications. Hence this study was designed to evaluate the effect of Conocarpus lancifolius extracts s to control multidrug-resistant bacteria. Chemical detection of aqueous extracts of Conocarpus lancifolius leaves revealed the presence of tannin, Saponins, Comarins, phenols, alkaloids, flavonoids, glycoside and terpenes compounds. Results showed yield of phenols extracts of C. lancifolius were 46.1% while yield of extracts 22.2% alkaloids. AgNPs was proved by Atomic Force Microscopy. The average diameter of 75.50 nm. HPLC analysis indicated the presence of four phenolic compounds were Rutin, Epigenen and Kamferol and Catechine while contains two alkaloids Scopolamine and Hyoscine. Results showed that Conocarpus lancifolius extracts and AgNPs, possess higher antibacterial activity against both gram-positive and gram-negative pathogenic bacteria

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