Eurasian Journal of Biosciences


Objective: The aim of performing this study was to reveal the anticipated effects of paroxetine on rats’ sperm parameters.
Materials and Methods: Twenty four adult male rats of 200-225 grams weight were adopted. Rats were randomly allocated into three groups; Control, Paroxetine 40mg, and Paroxetine 80mg. The experiment period was one month. The control group rats were dosed with distilled water. Paroxetine 40mg were dosed with 40 mg paroxetine hydrochloride and the Paroxetine 80mg group were dosed with 80 mg paroxetine hydrochloride. All groups were dosed orally and daily for one month.
Results: The results revealed that paroxetine causes significant decrease in sperm count and significant increase in dead and abnormal sperms when it was offered to rats as 40 mg/kg and it causes more significant bad effects when it was offered as 80 mg/ kg comparing among the treatment groups and with the control at (P≤0.05).
Conclusions: Paroxetine does effect rats’ sperm count and sperm availability and morphology.


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