Abstract

Objective: The aim of performing this study was to reveal the anticipated effects of paroxetine on rats’ sperm parameters.
Materials and Methods: Twenty four adult male rats of 200-225 grams weight were adopted. Rats were randomly allocated into three groups; Control, Paroxetine 40mg, and Paroxetine 80mg. The experiment period was one month. The control group rats were dosed with distilled water. Paroxetine 40mg were dosed with 40 mg paroxetine hydrochloride and the Paroxetine 80mg group were dosed with 80 mg paroxetine hydrochloride. All groups were dosed orally and daily for one month.
Results: The results revealed that paroxetine causes significant decrease in sperm count and significant increase in dead and abnormal sperms when it was offered to rats as 40 mg/kg and it causes more significant bad effects when it was offered as 80 mg/ kg comparing among the treatment groups and with the control at (P≤0.05).
Conclusions: Paroxetine does effect rats’ sperm count and sperm availability and morphology.

References

  • Albus, Udo. (2012) Guide for the Care and Use of Laboratory Animals (8th Edn).” Laboratory Animals 46.3, 267–268.
  • Al-Uboody WSH (2017). Pregabalin effects on cellular and humoral components of blood of mice (Mus musculus). Bas.J.Vet.Res. 16 (2): 76-84.
  • Al-Uboody WSH, Taher IA, Al-Fatlawi AHJ (2017) Gabapentin effects on lipid profile, Blood electrolytes, and functions of kidney and liver of laboratory mice (Mus musculus). Muthanna Medical Journal. 4(2): 135-140.
  • Amiridis G S, and Cseh S (2012) “Assisted Reproductive Technologies in the Reproductive Management of Small Ruminants.” Animal Reproduction Science 130.3–4,152–161.
  • Amodeo LR, Greenfield VY, Humphrey DE, Varela V, et al. 2015. Effects of acute or repeated paroxetine and fluoxetine treatment on affective behavior in male and female adolescent rats. Psychopharmacology (Berl). 232(19): 3515–3528.
  • Beeder L, Samplaski MK 2020. Effect of antidepressant medications on semen parameters and male fertility. International Journal of Urology. 27, 39-46.
  • Casilla-Lennon MM, Meltzer-Brody S, Steiner AZ, et al. (2016) The effect of antidepressants on fertility. Am J Obstet Gynecol. 215:314.e1-5.
  • David DJP, Bourin M, Jego G, Przybylski C, Jolliet P, Gardier AM (2003). Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. British Journal of Pharmacology. 140, 1128–1136.
  • EL-Gaafarawi I, Hassan M, Fouad G, El-Komey F (2005) Toxic effects of paroxetine on sexual and reproductive functions of rats. The Egyptian Journal of Hospital Medicine. 21: 16 – 32.
  • Erdemir F, Atilgan D, Firat F, Markoc F, Parlaktas BS, Sogut E (2014) The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats. Int Braz J Urol. 40: 100-8.
  • Figueira I, Nardi AE, Mendlowicz M, Marques C, Versiani M. (1997) the impact of SSRIs on personality traits and compulsive behaviors – case reports. J Bras Psiq. 46 (4): 227-230.
  • Fujinoki M (2011) Serotonin-enhanced hyperactivation of hamster sperm. Reproduction. 142: 255-66.
  • Goodman Gilman, A. (2017). Goodman & Gillman’s The Pharmacological Basis of Therapeutics. Mc Graw Hill Education.
  • Hanoon SA, Hashim WS, Arean AG (2020). Physiological effects of Prozac on cellular and Humoral components of blood of laboratory mice. International Journal of Pharmaceutical Research. 12 (4): 821-824.
  • Hashim WS, Arean AG, Waad SK (2020) Physiological Disturbances Caused by Citalopram in Rats. The Journal of Research on the Lepidoptera. 51 (2): 408-416.
  • Hendrick V, Gitlin M, Altshuler L, Korenman, S (2000) Antidepressant medications, mood and male fertility. Psychoneuroendocrinology. 25(1): 37-51.
  • Jiménez-Trejo F, Tapia-Rodrguez M, Queiroz DB, Padilla P, Avellar MC, Manzano PR, et al (2007) Serotonin concentration, synthesis, cell origin, and targets in the rat caput epididymis during sexual maturation and variations associated with adult mating status: morphological and biochemical studies. J Androl. 28: 136-49.
  • Kellner M (1997). Selective Serotonin Re-Uptake Inhibitors in the Environment Effects of Citalopram on Fish Behaviour. N.p., 2017. Print.
  • Marrison JL, Riggs KW, Chien C, Gruber N, McMillen IC, Rurak DW (2004) Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary- adrenal axis. Pediatr. Res. 56(1):40-46.
  • Ritter, James et al. A Textbook of Clinical Pharmacology and Therapeutics, 5Ed. CRC Press, (2008). A Textbook of Clinical Pharmacology and Therapeutics, 5Ed. Web.
  • Riva – paroxetine 2017. Product monograph. Laboratoire Riva Incorporation, Quebec.
  • Subcommittee on Laboratory Animal Nutrition (1995), Committee on Animal Nutrition, Board on Agriculture, National Research Council. Nutrient requirements of laboratory Animals. 4th revised Ed, National academy press, Washington DC, USA, pp: 1-175.
  • Syed V, Gomez E, Hecht NB (1999) Messenger ribonucleic acids encoding a serotonin receptor and a novel gene are induced in Sertoli cells by a secretedfactor(s) from male rat meiotic germ cells. Endocrinology. 140: 5754-60.
  • Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN (2010). Fertility and Sterility. 94 (3): 1021-1025.
  • Walsh MT, Dinan TG (2001). Selective serotonin reuptake inhibitors and violence: a review of the available evidence. Acta Psychiatr Scand. 104: 84-91.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.