Neuroprotective effects of Vitex agnus castus extract in rats’ model of Alzheimer’s disease

Abstract

Alzheimer’s disease (AD) is the most common degenerative neurological disorders and is characterized by a variety of symptoms such as memory loss, reduced of cognitive functions, abnormal behavior and psychiatric problems. Vitex agnus castus (Vac) has been reported to have both antioxidant and neuroprotective effects. The preset study was designed to study the effect of Vac extract in lipoploysacchride - induced AD - like features in rats. Material and method : Rats were divided equally (7 rats/group) into five groups; control group, induction group (rats were administered lipoploysacchride 250 μg/kg i.p. once daily for 7 days), and the further three treatment groups included rats received tested drugs prophylactically for 21 days then the induction done by lipoplysacchride (250 μg/kg) i.p. once daily together with continuation of the same oral doses of the tested drugs for further 7days; these treatment groups included donepezil group (0.5 mg/Kg orally once daily), VCA extract group (80mg/Kg orally once daily) and combination group (donepezil 0.5mg/Kg and Vac extract 80mg/Kg; both were administrated orally once daily). Behavioral parameters like Ymaze and novel object recognition were evaluated. Oxidative stress parameters and inflammatory cytokines were carried out in the sample of brain tissues. Result: vitex agnus castus extract have significant improvement in memory and cognition, and improve the level of oxidative stress parameter, and inflammatory cytokines.
Conclusion: The present study revealed the neuroprotective effect of Vac against lipopolysacchride-induced AD -like features in rats. Such beneficial effect seemed probably due to Vac significant antioxidant and anti-inflammatory effects as been proved in the present study.

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