Nerve growth factor and infertility status among infertile males in Kerbala city, Iraq

Abstract

Introduction: Nerve growth factor (NGF) is known to share a mutual effect regulating neuronal and reproduction functions.
Aim: To estimate the correlation of NGF with semen parameters, age, Body Mass Index, smoking and infertility duration.
Materials and Methods: Semen samples from 121 infertile males (40 asthenozoospermia, 41 oligoasthenozoospermia) and 40 normospermia (controls) were analyzed for NGF by ELIZA assay. Sperm parameters were assessed using the World Health Organization guidelines.
Results: The serum content of NGF positively correlated with age (r= 0.0367; p<0.018) in oligoasthenozoospermic subjects; yet the correlation did not reach a significant level in total infertile males (asthenozoospermic and oligoasthenozoospermic). No correlation was found between NGF in serum and seminal plasma and BMI, smoking status and infertility duration.
Conclusion: The study showed that Serum NGF positively correlated with age. Additional study using a large sample size is required to confirm these results.

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