Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats
Olga S. Shubina 1 * , Marina V. Egorova 1, Olga I. Komusova 1, Natalya A. Dudenkova 1, Vladimir S. Bardin 1, Lyudmila Y. Labzina 2, Margarita V. Labzina 2, Olga V. Kirdyashkina 2
1 Mordovian State Pedagogical Institute named after M.E. Evseviev, Saransk, RUSSIA2 Ogarev Mordovia State University, Saransk, RUSSIA
* Corresponding Author
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2019 - Volume 13 Issue 2, pp. 1791-1796
  • Published Online: 23 Nov 2019
  • Article Views: 255 | Article Download: 200
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Shubina OS, Egorova MV, Komusova OI, et al. Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats. Eurasia J Biosci. 2019;13(2), 1791-1796.

APA 6th edition
In-text citation: (Shubina et al., 2019)
Reference: Shubina, O. S., Egorova, M. V., Komusova, O. I., Dudenkova, N. A., Bardin, V. S., Labzina, L. Y., . . . Kirdyashkina, O. V. (2019). Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats. Eurasian Journal of Biosciences, 13(2), 1791-1796.

Chicago
In-text citation: (Shubina et al., 2019)
Reference: Shubina, Olga S., Marina V. Egorova, Olga I. Komusova, Natalya A. Dudenkova, Vladimir S. Bardin, Lyudmila Y. Labzina, Margarita V. Labzina, and Olga V. Kirdyashkina. "Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats". Eurasian Journal of Biosciences 2019 13 no. 2 (2019): 1791-1796.

Harvard
In-text citation: (Shubina et al., 2019)
Reference: Shubina, O. S., Egorova, M. V., Komusova, O. I., Dudenkova, N. A., Bardin, V. S., Labzina, L. Y., . . . Kirdyashkina, O. V. (2019). Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats. Eurasian Journal of Biosciences, 13(2), pp. 1791-1796.

MLA
In-text citation: (Shubina et al., 2019)
Reference: Shubina, Olga S. et al. "Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats". Eurasian Journal of Biosciences, vol. 13, no. 2, 2019, pp. 1791-1796.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Shubina OS, Egorova MV, Komusova OI, Dudenkova NA, Bardin VS, Labzina LY, et al. Morphometric studies of the cerebral cortex under exposure to lead acetate in albino rats. Eurasia J Biosci. 2019;13(2):1791-6.

Abstract

The broad review of anatomical studies allows stating that regulation of motions is associated with pyramidal neurons of stratum V of the cortex of cerebral hemispheres, with their axons forming the pyramidal tract. It is in the motor cortex that the extrapyramidal system originates which includes cerebellum, too. Certainly, this raises many questions, one of them being the action of heavy metals on neurons of various regions of the cortex of the cerebrum (the sensory, the motor ones) and various regions of the cerebellum. In order to perform the research, histological and morphometric analysis of neurons of the cerebellar cortex and somatosensory region of the neocortex of rats was applied using the Axio Imager.M2 (ZEISS, Japan) digital microscope with the AxioVision SE64 Rel. 4.8.3 and ZEN 2011 software. It has been shown that under the effect of lead acetate the thickness of the cerebellar cortex and the somatosensory region is reduced. A decrease in density of neurons per 0,001 mm3 of the brain matter has been registered in all strata of the cerebellar cortex and somatosensory cortex strata. The 31% increase (p <0,05) of the NCR of Purkinje cells of the cortex cerebellum as compared to the control group and their 3-fold reduction in the inner pyramidal stratum of the cortex somatosensory gives evidence about the opposite direction of compensatory responses of the brain regions under study. Intoxication of albino rats by lead acetate at the median toxic dose of 45 mg/kg/24 h causes marked histological changes in the cerebellar cortex and the somatosensory region confirmed by morphometric data.

Keywords

cerebellum somatosensory cortex lead acetate

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