Momordica charantia induces structural and functional changes in the stomach of male wistar rats
Tolulope Oluyemisi Oyesola 1 * , Anuoluwapo Adenike Adegboye 2, Olusoji Adebusoye Oyesola 2, Boone Ibiyinka Kukoyi 2
1 Department of Physiology, Babcock University, Ilishan Remo, Ogun state, NIGERIA2 Department of Physiology, Olabisi Onabanjo University, Ogun State, NIGERIA
* Corresponding Author
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2019 - Volume 13 Issue 2, pp. 1541-1547
  • Published Online: 14 Oct 2019
  • Article Views: 393 | Article Download: 280
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Oyesola TO, Adegboye AA, Oyesola OA, Kukoyi BI. Momordica charantia induces structural and functional changes in the stomach of male wistar rats. Eurasia J Biosci. 2019;13(2), 1541-1547.

APA 6th edition
In-text citation: (Oyesola et al., 2019)
Reference: Oyesola, T. O., Adegboye, A. A., Oyesola, O. A., & Kukoyi, B. I. (2019). Momordica charantia induces structural and functional changes in the stomach of male wistar rats. Eurasian Journal of Biosciences, 13(2), 1541-1547.

Chicago
In-text citation: (Oyesola et al., 2019)
Reference: Oyesola, Tolulope Oluyemisi, Anuoluwapo Adenike Adegboye, Olusoji Adebusoye Oyesola, and Boone Ibiyinka Kukoyi. "Momordica charantia induces structural and functional changes in the stomach of male wistar rats". Eurasian Journal of Biosciences 2019 13 no. 2 (2019): 1541-1547.

Harvard
In-text citation: (Oyesola et al., 2019)
Reference: Oyesola, T. O., Adegboye, A. A., Oyesola, O. A., and Kukoyi, B. I. (2019). Momordica charantia induces structural and functional changes in the stomach of male wistar rats. Eurasian Journal of Biosciences, 13(2), pp. 1541-1547.

MLA
In-text citation: (Oyesola et al., 2019)
Reference: Oyesola, Tolulope Oluyemisi et al. "Momordica charantia induces structural and functional changes in the stomach of male wistar rats". Eurasian Journal of Biosciences, vol. 13, no. 2, 2019, pp. 1541-1547.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Oyesola TO, Adegboye AA, Oyesola OA, Kukoyi BI. Momordica charantia induces structural and functional changes in the stomach of male wistar rats. Eurasia J Biosci. 2019;13(2):1541-7.

Abstract

Background: Medicinal plants are important as therapeutic and essential agents in health care programs, especially in developing countries. Momordica charantia known otherwise as bitter melon and also often described as food of medicine, is a herb with multiple medicinal uses. Momordica charantia has been known for a wide range of use in the treatment of various diseases as well as for preventive purposes but few studies have been reported on the stomach responsiveness to its administration The aim of this study was to investigate the effects of aqueous leaf of Momordica charantia on the integrity of the stomach by evaluating the effect on mucus concentration, acid secretion in the stomach, antioxidant enzymes activity and histomorphological changes.
Materials and Methods: Eighteen male rats weighing between 150 to 200g were placed into 3 groups of 6 rats each. Control group received water, and treated groups were given oral doses of 100mg/kg and 400mg/kg of the aqueous leaf extract of Momordica charantia for 30 days.
Results: There was a significant decrease in the gastric acid secretion, mucus concentration and antioxidant enzymes (glutathione, superoxide dismutase and catalase) in the two administered doses when compared with the control. From the histomorphological changes observed, there was an increase in mucosal degeneration and decrease in mucosa thickness.
Conclusion: A prolonged administration of aqueous leaf extract of Momordica charantia to rats induced gastric mucosal damage which could be related to decreased mucus concentration and acid production in the stomach via distortion caused to the cellular integrity of the gastric mucosa as well as reduced antioxidative enzymes.

Keywords

antioxidant enzymes gastric acid gastric mucus histomorphological changes Momordica charantia

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