Molecular docking and analysis of MEP2 protein in Candida albicans membrane
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 2, pp. 4373-4376
  • Published Online: 26 Oct 2020
  • Open Access Full Text (PDF)

Abstract

MEP2 is an important protein for the transportation of ammonium from outside to inner cell for metabolisms and nutrition in Candida albicans. The drug design technique is the best tool to obstruction important mechanism of pathogenic organisms. MEP2 contain identical chain (A and B) which make a crystal structure of protein. Molecular docking of the MEP2 protein has been done by using COACH-D web tool and analyzing the structure by CASTp tool. The results showed that there are three ligands which can be used as inhibitors for MEP2 protein activity, these ligands are NME, XE and NH3 can act and conjugated in many pockets within protein structure.

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