Asthma is the most common chronic respiratory disease with high prevalence throughout the world. The disease is known to be caused by a combination of genetic and environmental factors, including changes in lifestyle, urbanization and mainly air pollution. The study aimed to find some sociodemographic factors like age, gender, residency, family history, and also some immunological factors like CRP, IgE and IL-4 levels in asthmatic patients and compare them with the patients free from asthma. A total of (160) blood sample was collected from (80 diseases and 80 control ) patient attending from Rizgary hospital and the practical issue done in a private clinic and central public laboratory to obtain the serum to measure the (CRP) level, IgE level by using Coobas instrument and measurement the level of the IL-4 by using ELISA of both cases and controls done in central public health laboratory and king private laboratory in Erbil city. The mean age for asthmatic and control group was (36.55±13.3, 35.4 ±16.8) years respectively with the highest percentage of patients with asthma were in young age group(21-40)years which was 35(43.75%), and showed that asthma was higher in women(60%) than that in male which were (40%) and asthma was more common in the urban area (62.5%) than the rural area(37.2%). Regarding family history, this study showed that (63.75%) of asthmatic patients have a positive family history of one of the allergic diseases. Mean CRP level in asthmatic patients (7.4125±2.325 mg/ml) which was higher than control (3.937±4.77570mg/ml) and the mean level of IgE was (505.187±580.74968IU/ml) and for controls was (85.5433±185.04042IU/ml). The mean level of IL-4 for asthmatic patients was (1.1001±1.08497pg/ml) and was higher than control (0.0586±0.01032pg/ml). The highest percentage of asthma was in the young age group and more common in women than males, allergic asthma mostly associated with those they had a positive family history of asthma or any other allergic disease, and asthma is more common in an urban area than a rural area. The findings of this research indicate that serum CRP, IgE, and IL-4 in Asthma is higher than healthy control and can be used for assessing the severity and response to the treatment.

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