Abstract

Background: Spondyloarthritis (SpA) is an active chronic inflammatory disease involving pro-inflammatory cytokines; one of which is leptin. This study aimed to determine correlation between leptin serum level and disease activity in SpA patients.
Method: A cross-sectional study involving patients diagnosed with SpA was conducted according to the 2009 ASAS criteria. Leptin serum level is measured by using ELISA whilst disease activity in SpA by ASDAS-CRP. The correlation was analyzed using Spearman correlation test.
Results: Fifty subjects with SpA aged 54.3±9.32 years old showed mean body mass index of 23.63±3.05 kg/m2, CRP level of 0.76±0.91 mg/dL, ESR of 40.88±16.92 mm/hour, Schober test of 12.97±1.18 cm, and chest expansion test of 1.39±0.67 cm. Median leptin level and ASDAS-CRP score were 9.6 (0.92-51.57) ng/dL and 2.2 (1.3-3.86), respectively. No correlation was found between leptin level and disease activity (p = 0.174).
Conclusion: Leptin serum level cannot be used as a modality to assess disease activity in SpA.

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