Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2019 - Volume 13 Issue 2, pp. 1075-1079
  • Published Online: 10 Aug 2019
  • Article Views: 328 | Article Download: 165
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Mottahedzadeh R, Khatamsaz S, Mokhtari MJ. Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats. Eurasia J Biosci. 2019;13(2), 1075-1079.

APA 6th edition
In-text citation: (Mottahedzadeh et al., 2019)
Reference: Mottahedzadeh, R., Khatamsaz, S., & Mokhtari, M. J. (2019). Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats. Eurasian Journal of Biosciences, 13(2), 1075-1079.

Chicago
In-text citation: (Mottahedzadeh et al., 2019)
Reference: Mottahedzadeh, Razieh, Saeed Khatamsaz, and Mohammad Javad Mokhtari. "Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats". Eurasian Journal of Biosciences 2019 13 no. 2 (2019): 1075-1079.

Harvard
In-text citation: (Mottahedzadeh et al., 2019)
Reference: Mottahedzadeh, R., Khatamsaz, S., and Mokhtari, M. J. (2019). Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats. Eurasian Journal of Biosciences, 13(2), pp. 1075-1079.

MLA
In-text citation: (Mottahedzadeh et al., 2019)
Reference: Mottahedzadeh, Razieh et al. "Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats". Eurasian Journal of Biosciences, vol. 13, no. 2, 2019, pp. 1075-1079.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Mottahedzadeh R, Khatamsaz S, Mokhtari MJ. Investigating and comparing the effects of lead poisoning in the rate of Flt3 gene expression in Acute Myeloid Leukemia (AML) and the value of its proteins synthesis in adult male rats. Eurasia J Biosci. 2019;13(2):1075-9.

Abstract

Nowadays, cancer is undoubtedly one of the main and most common causes of human mortality. Recent studies have proved the origin and genetic source of many types of cancers. One of the main causes of genetic changes leading to the prevalence of cancer is exposure to various environmental pollutants in the living environment. The present study aims to investigate the possible effects of poisoning with lead compounds on the expression of an important gene of flt3 involved in the development of Leukemia in healthy rats. A total of 48 male rats were used in this study. Animals were generally divided into 6 groups, including control group, 300 mg / kg.bw sodium sulfide poisoning group, 600 mg / kg.bw sodium sulfide poisoning group, 30 mg / kg.bw lead acetate poisoning group, 60 mg / kg.bw lead acetate poisoning group, 600 mg / kg.bw sodium sulfide plus 60 mg / kg.bw lead acetate poisoning group. In this study, gavage was performed on rats for four months and blood samples were taken after this time. Using protein measurement kits, the value of protein was measured and it was found that in the group that received 600 mg / kg.bw sodium sulfide plus 60 mg / kg.bw lead acetate, the value of protein and gene expression increased significantly compared to other groups.

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