Interleukin-17 serum levels as a vital indicator of psoriatic Iraqi patients in Thi-Qar Province

Abstract

Psoriasis is a multifactor skin disorder, with immune-mediated inflammatory pathogenesis. Theories and studies illustrated the crucial role for Interleukin-17 (IL-17) in promotes the occurrence and severity of psoriasis. We measured the serum IL-17 levels for detection the importance and effects of IL-17 as predictors for the psoriasis disorders and its severity. Forty-five cases of psoriatic patients and the same number from healthy subjects as control were included in this study, the severity of psoriasis was determined by the Psoriasis Area and Severity Index (PASI). Patients were categorize according to severity as mild psoriasis in (21), and moderate to severe psoriasis group in (24), 3 ml sera samples of both groups were collected to estimate IL-17, The results showed that the majority of the patients comprised of age group 36-45 (42.0%), Female to male ratio in patients was 1.6:1. Serum IL-17 was significantly increasing among psoriatic patients as compared to healthy controls (895.066 pg/ml and 364.334 pg/ml) respectively. Also, there was a relation between an elevated IL-17 serum levels and Psoriasis severity of groups with highly significant difference. It can be concluded that (IL-17) has important role during the activity of psoriasis and should be a target for biological therapy in Iraqi psoriatic patients.

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