Interleukin 1β and cytotoxic T lymphocyte-associated antigen: Role in susceptibility to cytomegalovirus infections
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 2, pp. 3321-3325
  • Published Online: 21 Sep 2020
  • Open Access Full Text (PDF)

Abstract

Objective: Interleukin 1β is a powerful cytokine with a variety of inflammatory functions. This cytokine plays a role in many cellular activities including cell expansion, differentiation, and apoptosis. CTLA4 is an antigen expressed in T lymphocytes has a critical role as inhibitory receptor acting as a major negative regulator of T-cell responses. Material and Methods: Fifty samples of the blood were obtained from CMV patients and a safe control group, then DNA was extracted and analyzed for genotypes IL-1β and CTLA-4 and Alleles with (PCR) and Gel electrophoresis using 2,25%, 2% the concentration of agarose was (respectively) investigated. Results: IL-1β mutations were detected in 58 percent of CMV patients, Although only 44% were observed in the control group, we noticed a substantial correlation between the genotype and the allele frequency and the P<0.05 group of CMV infections. CTLA-4, the G allele correlates with a substantially reduced risk of CMV infections. Conclusion: IL-1β and CTLA-4 are associated with CMV infections.

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