Beaker yeast is one of a wide variety of fungi found in nature. The current study included investigating the inhabitability of Saccharomyces cerevisiae isolates on the growth of some negative bacteria that gram stain. The results showed that baking yeast varies in its ability to produce lethal toxins that inhibit the growth of some types of positive and negative bacteria of gram stain according to the nature of isolation and according to the company producing them effectiveness of baking yeast increases to produce toxins when grown at a temperature of 30 ° C. While the temperatures of 20 ° C and 37 ° C were not efficient in the production process pH has an effective role to increase its ability to produce toxins that inhibit the growth of other yeasts, the best of which was at = pH3.5

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