Calcium phosphate cements (CPCs) are promising for clinical applications due to their profitable properties counting bioactivity, osteoconductivity, injectability and moldability. Within the final few decades, significant effort and numerous studies have been committed to investigating and understanding the mechanisms under the problems in CPCs and to try to illuminate them, with shifting degrees of success. However, little is known of their relative mechanical properties. In this systematic review and meta-analysis, the mechanical strength and in vitro durability of calcium phosphate cements were evaluated. MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar were used as electronic databases to perform a systematic literature between 2010 to 2019. A commercially available software program (Endnote X9) was used for electronic title management. Searches were performed with keywords, “Calcium Phosphate Cements OR CPCs OR CPC”, “tetracalcium phosphate OR TTCP”,” α-tricalcium phosphate cement”,” β-tricalcium phosphate”, “dicalcium phosphate OR DCP” “Monocalcium phosphate OR MCP” , “hydroxyapatite”. The present systematic review was performed based on the main consideration of PRISMA Statement–Preferred Reporting Items for Systematic Reviews and Meta-analysis. A total of ninteen publications fulfilled the inclusion criteria required for this systematic review. In this Analysis To begin with, the compressive strength ranges of size over studies, from 0.1 to 103 MPa for porosities of 15-84%. Furthermore, in any case of the CPC composition (apatite or brushite), the strength diminishes all inclusive with expanding porosity, which could be a common event in materials science and has been widely observed in other permeable materials utilized for bone substitution. Apatite cements generally have higher strengths than brushite cements.


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