Abstract

Calcium phosphate cements (CPCs) are promising for clinical applications due to their profitable properties counting bioactivity, osteoconductivity, injectability and moldability. Within the final few decades, significant effort and numerous studies have been committed to investigating and understanding the mechanisms under the problems in CPCs and to try to illuminate them, with shifting degrees of success. However, little is known of their relative mechanical properties. In this systematic review and meta-analysis, the mechanical strength and in vitro durability of calcium phosphate cements were evaluated. MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar were used as electronic databases to perform a systematic literature between 2010 to 2019. A commercially available software program (Endnote X9) was used for electronic title management. Searches were performed with keywords, “Calcium Phosphate Cements OR CPCs OR CPC”, “tetracalcium phosphate OR TTCP”,” α-tricalcium phosphate cement”,” β-tricalcium phosphate”, “dicalcium phosphate OR DCP” “Monocalcium phosphate OR MCP” , “hydroxyapatite”. The present systematic review was performed based on the main consideration of PRISMA Statement–Preferred Reporting Items for Systematic Reviews and Meta-analysis. A total of ninteen publications fulfilled the inclusion criteria required for this systematic review. In this Analysis To begin with, the compressive strength ranges of size over studies, from 0.1 to 103 MPa for porosities of 15-84%. Furthermore, in any case of the CPC composition (apatite or brushite), the strength diminishes all inclusive with expanding porosity, which could be a common event in materials science and has been widely observed in other permeable materials utilized for bone substitution. Apatite cements generally have higher strengths than brushite cements.

References

  • Almirall A, Larrecq G, Delgado J, Martınez S, Planell J, Ginebra M. (2004). Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an α-TCP paste. Biomaterials. 25(17):3671-80. https://doi.org/10.1016/j.biomaterials.2003.10.066
  • Barralet J, Gaunt T, Wright A, Gibson IR, Knowles J. (2002). Effect of porosity reduction by compaction on compressive strength and microstructure of calcium phosphate cement. Journal of Biomedical Materials Research: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 63(1):1-9. https://doi.org/10.1002/jbm.1074
  • Bohner M. (2007). Reactivity of calcium phosphate cements. Journal of Materials Chemistry. 17(38):3980-6.
  • Brown WE. (1987). A new calcium phosphate, water-setting cement. Cements research progress. 351-79.
  • Calafiori A, Di Marco G, Martino G, Marotta M. (2007). Preparation and characterization of calcium phosphate biomaterials. Journal of Materials Science: Materials in Medicine. 18(12):2331-8.
  • Chen W, Zhou H, Tang M, Weir MD, Bao C, Xu HH. (2011). Gas-foaming calcium phosphate cement scaffold encapsulating human umbilical cord stem cells. Tissue Engineering Part A. 18(7-8):816-27. https://doi.org/10.1089/ten.tea.2011.0267
  • Chew K-K, Low K-L, Zein SHS, McPhail DS, Gerhardt L-C, Roether JA. (2011). Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications. Journal of the mechanical behavior of biomedical materials. 4(3):331-9.
  • Chow LC, Hirayama S, Takagi S, Parry E. (2000). Diametral tensile strength and compressive strength of a calcium phosphate cement: effect of applied pressure. Journal of Biomedical Materials Research: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 53(5):511-7.
  • Chow LC, Takagi S. (2001). A natural bone cement—A laboratory novelty led to the development of revolutionary new biomaterials. Journal of research of the National Institute of Standards and Technology. 106(6):1029. https://doi.org/10.6028/jres.106.053
  • Del Real R, Wolke J, Vallet-Regı M, Jansen J. (2002). A new method to produce macropores in calcium phosphate cements. Biomaterials. 23(17):3673-80.
  • Döbelin N, Tiainen H, Bohner M. (2017). Calcium phosphate cement composition. Google Patents.
  • Feng B, Guolin M, Yuan Y, Changshen L, Zhen W, Jian L. (2010). Role of macropore size in the mechanical properties and in vitro degradation of porous calcium phosphate cements. Materials Letters. 64(18):2028-31.
  • Ginebra MP, Delgado JA, Harr I, Almirall A, Del Valle S, Planell JA. (2007). Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam. Journal of Biomedical Materials Research Part A. 2007;80(2):351-61.
  • Gunnella F. (2018). Biotechnologically modified calcium phosphate cement for the stabilization of osteoporotic vertebral compression fractures: Friedrich-Schiller-University of Jena.
  • Guo H, Su J, Wei J, Kong H, Liu C. (2009). Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering. Acta biomaterialia. 5(1):268-78. https://doi.org/10.1016/j.actbio.2008.07.018
  • Habraken WJ, Zhang Z, Wolke JG, Grijpma DW, Mikos AG, Feijen J. (2008). Introduction of enzymatically degradable poly (trimethylene carbonate) microspheres into an injectable calcium phosphate cement. Biomaterials. 29(16):2464-76.
  • Hofmann M, Mohammed A, Perrie Y, Gbureck U, Barralet J. (2009). High-strength resorbable brushite bone cement with controlled drug-releasing capabilities. Acta biomaterialia. 5(1):43-9.
  • Ishikawa K, Asaoka K. (1995). Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement. Journal of biomedical materials research. 29(12):1537-43.
  • Kharkova NV, Reshetov IV, Zelianin AS, Philippov VV, Sergeeva NS, Sviridova IK, Komlev VS, Andreeva UU, Kuznecova OA (2019) Three-dimensional TCP scaffolds enriched with Erythropoietin for stimulation of vascularization and bone formation. Electronic Journal of General Medicine 16(2): em115. https://doi.org/10.29333/ejgm/108620
  • Li M, Liu X, Liu X, Ge B, Chen K. (2009). Creation of macroporous calcium phosphate cements as bone substitutes by using genipin-crosslinked gelatin microspheres. Journal of Materials Science: Materials in Medicine. 20(4):925-34.
  • Liu H, Li H, Cheng W, Yang Y, Zhu M, Zhou C. (2006). Novel injectable calcium phosphate/chitosan composites for bone substitute materials. Acta Biomaterialia. 2(5):557-65. https://doi.org/10.1016/j.actbio.2006.03.007
  • Liu W, Zhang J, Weiss P, Tancret F, Bouler J-M. (2013). The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution. Acta biomaterialia. 9(3):5740-50.
  • Lopez-Heredia MA, Sariibrahimoglu K, Yang W, Bohner M, Yamashita D, Kunstar A. (2012). Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement. Acta biomaterialia. 8(1):404-14.
  • Montufar E, Traykova T, Gil C, Harr I, Almirall A, Aguirre A. (2010). Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration. Acta Biomaterialia. 6(3):876-85. https://doi.org/10.1016/j.actbio.2009.10.018
  • Müller FA, Gbureck U, Kasuga T, Mizutani Y, Barralet JE, Lohbauer U. (2007). Whisker‐Reinforced Calcium Phosphate Cements. Journal of the American Ceramic Society. 90(11):3694-7.
  • Nezafati N, Moztarzadeh F, Hesaraki S, Mozafari M. (2011). Synergistically reinforcement of a self-setting calcium phosphate cement with bioactive glass fibers. Ceramics International. 37(3):927-34.
  • Panic N, Leoncini E, De Belvis G, Ricciardi W, Boccia S. (2013). Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PloS one. 8(12):e83138.
  • Pecqueux F, Tancret F, Payraudeau N, Bouler J. (2010). Influence of microporosity and macroporosity on the mechanical properties of biphasic calcium phosphate bioceramics: Modelling and experiment. Journal of the European Ceramic Society. 30(4):819-29. https://doi.org/10.1016/j.jeurceramsoc.2009.09.017
  • Saint-Jean SJ, Camire C, Nevsten P, Hansen S, Ginebra M. (2005). Study of the reactivity and in vitro bioactivity of Sr-substituted α-TCP cements. Journal of Materials Science: Materials in Medicine. 16(11):993.
  • Sakai S, Anada T, Tsuchiya K, Yamazaki H, Margolis HC, Suzuki O. (2016). Comparative study on the resorbability and dissolution behavior of octacalcium phosphate, β-tricalcium phosphate, and hydroxyapatite under physiological conditions. Dental materials journal. 35(2):216-24.
  • Senchi AA, Malami AA. (2015). Profitability of Non-Timber Forest Products (NTFPS) Production and Marketing in Zuru Local Government Area, Kebbi State: A Case for Honey. International Journal of Sustainable Agricultural Research, 2(2): 55-65.
  • Wagh A, Singh J, Poeppel R. (1993). Dependence of ceramic fracture properties on porosity. Journal of materials science. 28(13):3589-93. https://doi.org/10.1007/BF01159841
  • Weir MD, Xu HH. (2010). Osteoblastic induction on calcium phosphate cement–chitosan constructs for bone tissue engineering. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 94(1):223-33.
  • Xu HH, Wang P, Wang L, Bao C, Chen Q, Weir MD. (2018). Calcium phosphate cements for bone engineering and their biological properties. Bone research. 5:17056.
  • Zhang J, Liu W, Schnitzler V, Tancret F, Bouler J-M. (2014). Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties. Acta biomaterialia. 10(3):1035-49. https://doi.org/10.1016/j.actbio.2013.11.001
  • Zhang J, Tancret F, Bouler J-M. (2011). Fabrication and mechanical properties of calcium phosphate cements (CPC) for bone substitution. Materials Science and Engineering. 31(4):740-7.
  • Zhang J. (2012). Fabrication et propriétés mécaniques de ciments phosphocalciques poreux pour la substitution osseuse: Nantes.
  • Zhang Y, Xu HH, Takagi S, Chow LC. (2006). In-situ hardening hydroxyapatite-based scaffold for bone repair. Journal of Materials Science: Materials in Medicine. 17(5):437-45. https://doi.org/10.1007/s10856-006-8471-z

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