Frailty and age dynamics of separate clinical indicators in patients of therapeutic profile
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 2, pp. 4023-4028
  • Published Online: 17 Oct 2020
  • Open Access Full Text (PDF)

Abstract

Age-related dynamics of body homeostasis individual indicators in patients with risk of developing frailty and without frailty was studied in the research. Clinical indicators mostly associated with age were determined: muscle strength, glomerular filtration rate, total protein, potassium, hemoglobin, alanine aminotransferase activity, and blood plasma glucose. The contribution of reduced overall renal function, as well as anabolic activity of the liver in the development of age-related changes and frailty was studied. The important role of the renal function condition in the development of geriatric syndromes was noted, which must be taken into account when conducting therapeutic and rehabilitation measures for elderly and senile patients. It was noted that age-associated integral indicators, such as body weight and muscle strength, change noticeably more significantly than individual biochemical constants. This confirms the multiple nature of pathogenetic mechanisms and the role of comorbidity in the formation of geriatric syndromes, in particular, frailty.

References

  • Arango-Lopera, V.E., Arroyo, P., Gutiérrez-Robledo, L.M., Perez-Zepeda, M.U., Cesari, M. 2013. Mortality as an adverse outcome of sarcopenia. J. Nutr. Health. Aging, 17(3): 259-262.
  • Bezdenezhnykh, A.V., Sumin, A.N., 2012. Sarcopenia: prevalence, detection and clinical significance. Clinical Medicine, 10:16-22. (In Russian).
  • Bonnefoy, M., Berrut, G., Lesourd, B. et al., 2015. Frailty and nutrition: searching for evidence. The Journal of Nutrition, Health and Aging, 19(3): P.250–257.
  • Boytsov, S.A. et al., 2017. Guidelines for preventive counseling of patients 75 years of age and older in order to prevent the development and progress of frailty, M., 21. (In Russian).
  • Gorelik, S.G., Ilnitsky, A.N., Osipova, O. A., Khmelnitsky, A.V., Bulgakova, S.V., 2018. Course of Acute Coronary Syndrome in patients with Frailty. Indo American Journal of Pharmaceutical Sciences, 5 (7): 6992-6997.
  • Koroukian, S.M., Schiltz, N.K., Warner, D.F., Sun, J., Stange, K.C., Given, C.W., Dor, A., at al., 2017. Multimorbidity: constellations of conditions across subgroups of midlife and older individuals, and related Medicare expenditures. Journal of Comorbidity, 7(1):33–43.
  • Lazebnik, L.B., Efremov, L.I., Konev, Yu.V., 2015. Semantic difficulties at polymorbidity. Clinical Gerontology, 3: 44-46. (In Russian).
  • Mubang, R.N., Stoltzfus, J.C., Cohen, M.S. et al., 2015. Comorbidity-Polypharmacy Score as Predictor of Outcomes in Older Trauma Patients: A Retrospective Validation Study. World J Surg., 39(8):2068–2075.
  • Noskov, S. N., Zavodchikov, A. A., Lavrukhina, A. A., Gulneva, M.Yu., Tsurko, V.V., 2015. The clinical significance of myopenia and sarcopenia. Clinical Gerontology, 5-6: 46-50. (In Russian).
  • Paddon-Jones, D. and Leidy, H., 2014. Dietary protein and muscle in older persons. Current Opinion in Clinical Nutrition and Metabolic Care, 17(1): 5–11.
  • Pathak, A., Jain, L., Jaiswal, P. et al., 2016. To study the clinical profile of chronic kidney disease and associated comorbidities in geriatric patients. Int J Res Med Sci.,4(7): 3002-3008.
  • Prashchayeu, K.I., Ilnitski, A.N., Bocharova, K.A., Gerasimenko, A.V., 2016. Association of sarcopenia with fall syndrome. Osteoporosis and Osteopathy, 2: 109-110. (In Russian).
  • Prashchayeu, K.I., Ilnitski, A.N., Pozdnyakova N. et al., 2016. Syndrome of acute functional deficiency. Vrach (The Doctor), 6: 23-25(In Russian).
  • Raiche, M., Hebert, R., Dubois, M-F., 2008. PRISMA-7: a case- finding tool to identify older adults with moderate to severe disabilities. Arch. Gerontol. Geriatr., 47(1): 9–18.
  • Rymkiewicz, P., Ravani, P., Hemmelgarn, B.R., McAlister, F.A., Southern, D. A., Walker, R. et al., 2016. Effects of longitudinal changes in Charlson comorbidity on prognostic survival model performance among newly diagnosed patients with hypertension. BMC Health Services Research., 16: 671-677.
  • Sychev, D.A., 2016. Polypharmacy in clinical practice: problems and solutions. Science editor Otdelyonov V.A. - St. Petersburg: Professija, 224 p. (In Russian).
  • Tkacheva, O.N., 2018. Clinical recommendations: frailty, 106 p. (In Russian).
  • Tkacheva, O.N., Kotovskaya, Yu.V., Runikhina, N.K., Ostapenko, V.S., 2017. Features of clinical approaches to management of patients with frailty. RMJ (Russian Medical Journal), 25: 1823–1825. (In Russian).
  • Tkacheva, O.N., Pereverzev, A.P., Runikhina, N.K. et al., 2017. Optimization of drug prescriptions in elderly and senile patients: can polypharmacy be defeated? RMJ (Russian Medical Journal), 25: 1826–1828. (In Russian).
  • Tkacheva, O.N., Runikhina, N.K., Kotovskaya, Yu.V. et al., 2017. Frailty: what does a primary care physician need to know about it? RMJ (Russian Medical Journal), 25: 1820–1822. (In Russian).
  • Tkacheva, O.N., Runikhina, N.K., Ostapenko, V.S. et al., 2017. Validation of the questionnaire for screening frailty in outpatient practice. Advances in Gerontology, 30(2): 236-242. (In Russian).

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.