Age-related dynamics of body homeostasis individual indicators in patients with risk of developing frailty and without frailty was studied in the research. Clinical indicators mostly associated with age were determined: muscle strength, glomerular filtration rate, total protein, potassium, hemoglobin, alanine aminotransferase activity, and blood plasma glucose. The contribution of reduced overall renal function, as well as anabolic activity of the liver in the development of age-related changes and frailty was studied. The important role of the renal function condition in the development of geriatric syndromes was noted, which must be taken into account when conducting therapeutic and rehabilitation measures for elderly and senile patients. It was noted that age-associated integral indicators, such as body weight and muscle strength, change noticeably more significantly than individual biochemical constants. This confirms the multiple nature of pathogenetic mechanisms and the role of comorbidity in the formation of geriatric syndromes, in particular, frailty.

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