First record of Cyberlindnera fabianii that causes Vulvovaginitis in Iraq
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 1253-1255
  • Published Online: 12 Jun 2020
  • Open Access Full Text (PDF)


Background and Purpose: Cyberlindnera fabianii is a yeast present in soil rarely cause infection. Due to advanced diagnostic and therapeutic techniques, pathogenicity is increasingly recognized.
Case report: This report describes a case of a 41- years old Iraqi female with pruritus and vaginal irritation. Conventional tests and molecular analysis of the sample of vaginal discharge were performed. The mentioned analysis revealed Cyberlindnera fabianii as the causative agent of vaginal infection.
Conclusion: C. fabianii was found to have the ability to cause vulvovaginitis. This is the first record of successful detection of C. fabianii in vulvovaginal region.


  • Abi-Said D, Anaissie E, Uzun O, Raad I, Pinzcowski H, Vartivarian S (1997) The epidemiology of hematogenous candidiasis caused by different Candida species. Clin Infect Dis 24: 1122-1128.
  • Al-khawaja YA, Zghair FS (2020) First record of Cryptococcus gattii (VGI) that causes Vulvovaginitis in Iraq. Indian Journal of Public Health Research and Development, 11(4).
  • Arendrup MC (2010) Epidemiology of invasive candidiasis. Curr Opin Crit Care 16: 445-452.
  • Bhally HS, Jain S, Shields C, Halsey N, Cristofalo E, Merz WG (2006) Infection in a neonate caused by Pichia fabianii: importance of molecular identification. Medical Mycology, 44(2): 185-187.
  • Dooley DP, Beckius ML, McAllister CK, Jeffery BS (1990) Prostatitis caused by Hansenula fabianii. Journal of Infectious Diseases, 161(5): 1040-1041.
  • Freel KC, Sarilar V, Neuveglise C, Devillers H, Friedrich A, Schacherer J (2014) Genome sequence of the yeast Cyberlindnera fabianii (Hansenula fabianii). Genome Announcements, 2(4).
  • Gabriel F, Noel T, Accoceberry I (2012) Lindnera (Pichia) fabianii blood infection after mesenteric ischemia. Medical Mycology, 50(3): 310-314.
  • Grenouillet F, Millon L, Chamouine A, Thiriez G, Schulze O, Leroy J (2010) Pichia fabianii fungemia in a neonate. Pediatric Infectious Disease Journal, 29(2): 191.
  • Hamal P, Ostransky J, Dendis M, et al. (2008) A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. Medical Mycology, 46(6): 601-605.
  • Hazen KC (1995) New and emerging yeast pathogens. Clin Microbiol Rev 8: 462-478.
  • Kurtzman CP, Robnett CJ, Basehoar-Powers E (2008) Phylogenetic relationships among species of Pichia, Issatchenkia and Williopsis determined from multigene sequence analysis, and the proposal of Barnettozyma gen. nov., Lindnera gen. nov. and Wickerhamomyces gen. nov. FEMS Yeast Research, 8(6): 939-954.
  • Makimura K, Tamura Y, Mochizuki T, Hasegawa A, Tajiri Y, Hanazawa R, et al. (1999) Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions. J Clin Microbiol, 37(4): 920-924.
  • Melese GT, Tsegay BA, Kassa GM, Kuratie GB (2018) Patterns of Plant Community Formation and Vegetation Structure in the Afro-Alpine Vegetation of Simien Mountains National Park, Ethiopia. The International Journal of Biotechnology, 7(1): 31-43.
  • Merritt AE, Hurley R (1972) Evaluation of sporulation media for yeasts obtained from pathological material. Journal of Medical Microbiology, 5(1): 21-30.
  • Mlinaric-Missoni EH, Hatvani L, Kocsube S, Vagvolgyi C, Skaric I, Lukic-Grlic A (2015) Cyberlindnera fabianii in the neonatal and paediatric intensive care unit: case reports. JMM Case Reports, 2(3).
  • Pfaller MA, Houston A, Coffmann S (1996) Application of CHROMagar Candida for rapid screening of clinical specimens for Candida albicans, Candida tropicalis, Candida krusei, and Candida (Torulopsis) glabrata. J Clin Microbiol, 34(1): 58-61.
  • Valenza G, Valenza R, Brederlau J, Frosch M, Kurzai O (2006) Identification of Candida fabianii as a cause of lethal septicaemia . Mycoses, 49(4): 331-334.
  • White TJ, Bruns T, Lee S, Taylor J (1990) Amplification and direct sequencing of fungal ribosomal RNA grnes for phylogenetics in PCR protocols: Aguide to methods and application (innis M. A.gelfand D.H. Sninsky J.J. White T.J. Eds.), pp. 315-322. Academic press, San Diego,CA.
  • Wickerham LJ (1965) New Heterothallic species of Hansenula. Mycopathologia etMycologia Applicata, 26(1): 79-86.
  • Wu Y, Wang J, Li W, et al. (2013) Pichia fabianii blood infection in a premature infant in China: case report. BMC Research Notes, 6(77).
  • Yun JW, Park KS, Ki CS, Lee NY (2013) Catheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient. Journal of Medical Microbiology, 62(6): 922-925.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.