Evaluation of some biochemical levels in patients with Cutaneous leishmaniasis serum and their relationship with antioxidant enzymes
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 1999-2006
  • Published Online: 30 Jun 2020
  • Open Access Full Text (PDF)


The study aimed to know the levels of trace elements in the serum of patients with cutaneous leishmaniasis as well as some anti-oxidant elements and their relationship, where copper recorded a significant increase in the infected group mean±SD (777.01 ± 95.98 ppb) compared to the control group (667.1 ± 134.10 ppb). The serum iron level showed significant decrease in the infection group (801.33 ± 87.41 ppb) compared to the control group (879.4 ± 98.23 ppb). Serum selenium levels were significantly lower for the infected group (22.39 ± 8.6 ppb) compared to control group (33.96 ± 4.6 ppb). Also, the levels of zinc in the serum of the ingected group recorded a significant decrease of (1.04 ± 0.4 ppm) compared to the control group (1.17 ± 0.3 ppm). With regard to the levels of metallic oxidation of malondialdehyde in the group of cutaneous leishmaniasis, it recorded a significant increase (2.543 ± 0.419 µmol / L) compared to the group of control that recorded (1.720 ± 0.184 µmol / L). Antioxidant enzymes recorded statistically significant variations that included a significant (P <0.05) decrease of glutathione peroxidase antioxidant in patients with cutaneous leishmaniasis (291.59 ± 149.79 pg / ml) compared to the group of control subjects (339.69 ± 132.07 pg / ml). A significant elevation (P< 0.05) of Superoxide dismutase antioxidant was observed in patients with cutaneous leishmaniasis (0.0314 ± 0.026 pg / ml) compared to the control group of patients (0.128 ± 0.09 pg / ml). Whereas, the catalysts recorded a significant decrease in patients with cutaneous leishmaniasis (3.856 ± 0.76 U / mL) compared to the control group (4.607 ± 0.447 U / mL).


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