Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice
Suwoyo 1, Muhaimin Rifa’i 2 * , Widodo 2, Sasmito Djati 2
1 Doctoral Program of Environmental Science, Brawijaya University, INDONESIA2 Department of Biology, Faculty of Mathematics and Life Sciences, Brawijaya University, Jalan Veteran, Malang, East Java 65145, INDONESIA
* Corresponding Author
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 233-238
  • Published Online: 01 Mar 2020
  • Article Views: 62 | Article Download: 43
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Suwoyo, Rifa’i M, Widodo, Djati S. Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice. Eurasia J Biosci. 2020;14(1), 233-238.

APA 6th edition
In-text citation: (Suwoyo et al., 2020)
Reference: Suwoyo, Rifa’i, M., Widodo, & Djati, S. (2020). Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice. Eurasian Journal of Biosciences, 14(1), 233-238.

Chicago
In-text citation: (Suwoyo et al., 2020)
Reference: Suwoyo, Muhaimin Rifa’i, Widodo, and Sasmito Djati. "Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice". Eurasian Journal of Biosciences 2020 14 no. 1 (2020): 233-238.

Harvard
In-text citation: (Suwoyo et al., 2020)
Reference: Suwoyo, Rifa’i, M., Widodo, and Djati, S. (2020). Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice. Eurasian Journal of Biosciences, 14(1), pp. 233-238.

MLA
In-text citation: (Suwoyo et al., 2020)
Reference: Suwoyo et al. "Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice". Eurasian Journal of Biosciences, vol. 14, no. 1, 2020, pp. 233-238.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Suwoyo, Rifa’i M, Widodo, Djati S. Evaluating bioactivity of benzo[a]pyrene toward expression of cd4+cd62l+, cd8+cd62l+, and cd4+ifnÿ in the biology of measles paramyxovirus-vaccinated mice. Eurasia J Biosci. 2020;14(1):233-8.

Abstract

Current prevention strategies suggest that immunization is still the best option against measles and can manipulate the biologic characters of these viruses. However, immunization is often ineffective in a number of children because of the biological trait of different ages. To a significant extent, this phenomenon is caused by internal and external factors that influence children’s immunity. One of the external factors in this regard is the benzo[a]pyrene pollutant, both directly and indirectly. Accumulated benzo[a]pyrene can infiltrate deoxyribonucleic acid (DNA) to form benzo[a]pyrene and AhR bonds (Aryl Hydrocarbon Receptor). Such bonds affect the differentiation of immune cells, resulting in immunosuppressive activity. This study aims to analyze the bioactivity of benzo[a]pyrene with respect to the expression of CD4+CD62L+, CD8+CD62L+, and CD4+IFNŸ in a measles paramyxovirus-vaccinated mouse. Approximately 20 mg/kg BW of benzo[a]pyrene was injected using an intramuscular approach twice per week for one month. Furthermore, flow cytometric analysis was performed to determine immune cell expression. The results showed that mice under-vaccination and benzo[a]pyrene treatment suppress the expression of CD4+CD62L+ naïve T cells, increases the expression of CD8+CD62L+ naïve T cells, and reduces the expression of CD4+IFNŸ. Controlling internal and external factors enhanced the effectiveness of measles immunization in children.

Keywords

Benzo[a]pyrene measles paramyxovirus vaccine CD4+CD62L+ CD8+CD62L+ CD4+IFNŸ

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