Aim: the aim of the present systematic review and meta-analysis was evaluate the levels changes of periodontal pathogens in children during orthodontic treatments.
Method: From the electronic databases, PubMed, Cochrane Library, Embase, ISI have been used to perform a systematic literature until September 2020. Therefore, a software program (Endnote X8) has been utilized for managing the electronic titles. Searches were performed with mesh terms. Odds ratio between before and one or three months after treatment with 95% confidence interval (CI), Mantel-Haenszel method were calculated. Random effects were used to deal with potential heterogeneity and I2 showed heterogeneity. The Meta analysis and forest plots have been evaluated with the use of a software program available in the market (i.e., Comprehensive Meta-Analysis Stata V16).
Result: A total of 46 potentially relevant titles and abstracts were found during the electronic and manual search. Finally, a total of three publications fulfilled the inclusion criteria required for this systematic review. Odds ratio of P.gingivalis was (OR, -0.58 95% CI -1.34, 0.18. P= 0.14) and
Odds ratio of T. forsythensis was (OR, -1.44 95% CI -2.16, 0.73. P= 0.00), also odds ratio of P. intermedia was (OR, -1.09 95% CI -2.09, -0.10. P= 0.03).
Conclusion: The present systematic review and met analysis showed the levels of periodontal pathogens in children during orthodontic treatments was increased after orthodontic treatments vs before orthodontic treatments. Only no change in P.gingivalis was observed.


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