Background and aim: laser treatment protocols are challenging and the most effective method with desirable and excellent results is controversial, so the present study aims to evaluate the efficacy of laser therapy in root canal disinfection with different irrigants protocols.
Method: From the electronic databases, PubMed, Cochrane Library, Embase, ISI have been used to perform a systematic literature between 2010 and 2020. Therefore, a software program (Endnote X8) has been utilized for managing the electronic titles. Searches were performed with mesh terms.
Result: A total of 26 potentially relevant titles and abstracts were found during the electronic and manual search. Finally, a total of five publications fulfilled the inclusion criteria required for this systematic review. Mean difference of photodynamic therapy and control group was (MD, -3.29 95% CI -3.80, -2.79. P= 0.00) among five studies
Conclusion: The results show that the use of antimicrobial photodynamic therapy can be considered as an alternative to conventional treatment.

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