The study aimed to investigate the protective effect of SSO against toxicity of TMX and enhances fertility criteria. The study included 25 female mice randomly divided to five groups, were rodent chow and water given ad libitum. First group served as control, 2^nd group included ovariectomized mice, 3^rd group received TMX 0.5 mg/kg, 4^th group received SSO 5ml/kg, and 5^th group received TMX + SSO.
Blood samples were collected and serum were kept in deep freeze (-20 c). Biochemical tests carried out for detection of ALT, AST, ALP, urea, uric acid and creatinin in addition to hormonal assay estrogen, progesterone, FSH and LH. Histological study carried out after laporatomy to estimate thickness of uterine wall, and diameter with number of uterine glands, while ovarian specimen used to calculate number of follicles and corpus luteum.
The results of the study recorded significant increase (p<0.05) in the hepatic enzymes and renal function test parameters in TMX group, also the same results were recorded in OVX group except AST, ALP and creatinin parameters. While SSO + TMX group not recorded significant differences (p>0.05) in above parameters and in the concentration of studied hormones. Number of ovarian follicles and corpus luteum recorded a significant decrease (p<0.05) in TMX treated group, but recorded non significant differences (p>0.05) when co-treated with SSO, but there was a significant increase (p<0.05) in the diameter and number of uterine glands. Concluded co-treatment SSO with TMX have protective and enhancement effect on some physiological and fertility parameters.

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