Enhancement effect of sesame seeds oil on some physiological parameters in the serum of female mice treated with tamoxifen

Abstract

The study aimed to investigate the protective effect of SSO against toxicity of TMX and enhances fertility criteria. The study included 25 female mice randomly divided to five groups, were rodent chow and water given ad libitum. First group served as control, 2nd group included ovariectomized mice, 3rd group received TMX 0.5 mg/kg, 4th group received SSO 5ml/kg, and 5th group received TMX + SSO.
Blood samples were collected and serum were kept in deep freeze (-20 c). Biochemical tests carried out for detection of ALT, AST, ALP, urea, uric acid and creatinin in addition to hormonal assay estrogen, progesterone, FSH and LH. Histological study carried out after laporatomy to estimate thickness of uterine wall, and diameter with number of uterine glands, while ovarian specimen used to calculate number of follicles and corpus luteum.
The results of the study recorded significant increase (p<0.05) in the hepatic enzymes and renal function test parameters in TMX group, also the same results were recorded in OVX group except AST, ALP and creatinin parameters. While SSO + TMX group not recorded significant differences (p>0.05) in above parameters and in the concentration of studied hormones. Number of ovarian follicles and corpus luteum recorded a significant decrease (p<0.05) in TMX treated group, but recorded non significant differences (p>0.05) when co-treated with SSO, but there was a significant increase (p<0.05) in the diameter and number of uterine glands. Concluded co-treatment SSO with TMX have protective and enhancement effect on some physiological and fertility parameters.

References

  • Abbasi, Z., Tabatabaei, S. R. F., Mazaheri, Y., Barati, F., & Morovvati, H. (2013). Effects of sesame oil on the reproductive parameters of diabetes mellitus-induced male rats. The world journal of men's health, 31(2), 141-149.
  • Abou-Gharbia, H. A., Shehata, A. A. Y., & Shahidi, F. (2000). Effect of processing on oxidative stability and lipid classes of sesame oil. Food research international, 33(5), 331-340.
  • Al-Mafrajy, A. S. H., & Abass, K. S. (2019). Effect of Trifloralin herbicide on emergence, growth and seed production of wild Oat (Avena fatua L.) under different depth. EurAsian Journal of Biosciences, 13(2).
  • AL-Sallami, A. S. (2017). Effect of sesame oil on male rats treated with acrylamide in some physiological and hormonal blood criteria. Int J Curr Pharm Res, 134-140.
  • Amir, E., Freedman, O. C., Seruga, B., & Evans, D. G. (2010). Assessing women at high risk of breast cancer: a review of risk assessment models. JNCI: Journal of the National Cancer Institute, 102(10), 680-691.
  • Anitha, U., & Karuppasamy, R. (2011). Sesame meal administration attenuate the high-fat diet induced lipid abnormalities and improve insulin sensitivity in wistar rats. Int J Phar. Bio. Sci, 2(4).
  • Armenti, A. E., Zama, A. M., Passantino, L., & Uzumcu, M. (2008). Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats. Toxicology and applied pharmacology, 233(2), 286-296.
  • Aslam, F., Iqbal, S., Nasir, M., Anjum, A. A., Swan, P., & Sweazea, K. (2017). Evaluation of white sesame seed oil on glucose control and biomarkers of hepatic, cardiac, and renal functions in male Sprague-Dawley rats with chemically induced diabetes. Journal of medicinal food, 20(5), 448-457.
  • Atef E. El-Baky A. (2018). Antioxidant effects of sesame seed oil and their impact in improving male fertility of normal and diabetic rats. European Journal of Pharmaceutical and medical research. 5(2), 70-76.
  • Behrouj, H., Ziamajidi, N., Abbasalipourkabir, R., Nasiri, A., & Asl, S. S. (2015). Therapeutic effect of Silybum marianum plant extract on tamoxifen-induced fatty liver in rats. Avicenna Journal of Medical Biochemistry, 3(1), 5-27160.
  • Bernard, D. J., Fortin, J., Wang, Y., & Lamba, P. (2010). Mechanisms of FSH synthesis: what we know, what we don't, and why you should care. Fertility and sterility, 93(8), 2465-2485.
  • Bhuvaneswari, P., & Krishnakumari, S. (2012). Nephroprotective effects of ethanolic extract of Sesamum indicum seeds (Linn.) in streptozotocin induced diabetic male albino rats. International Journal of Green Pharmacy (IJGP), 6(4).
  • Boolbol, S. K., & Cate, S. P. (2015). Role of ablation in the treatment of breast cancer: A review. World J Surg Proced, 5(1), 106-110.
  • Boon, M. E., Kok, L. P., & Ouwerkerk‐Noordam, E. (1986). Microwave‐stimulated diffusion for fast processing of tissue: reduced dehydrating, clearing, and impregnating times. Histopathology, 10(3), 303-309.
  • Borai, I. H., Atef, A. A., El-Kashoury, A. A., Mohamed, R. A., & Said, M. M. (2019). Ameliorative effects of sesame seed oil against penconazole-induced testicular toxicity and endocrine disruption in male rats. Biomed J Sci Tech Res, 14(1), 10365-10375.
  • Boulbaroud, S., El-Hessni, A., Azzaoui, F. Z., & Mesfioui, A. (2012). Sesame seed oil and flaxseed oil affect plasma lipid levels and biomarkers of bone metabolism in ovariectomized Wistar rats. Biology and Medicine, 4(3), 102.
  • Braems, G., Denys, H., De Wever, O., Cocquyt, V., & Van den Broecke, R. (2011). Use of tamoxifen before and during pregnancy. The oncologist, 16(11), 1547.
  • Chen, P. R., Chien, K. L., Su, T. C., Chang, C. J., Liu, T. L., Cheng, H., & Tsai, C. (2005). Dietary sesame reduces serum cholesterol and enhances antioxidant capacity in hypercholesterolemia. Nutrition research, 25(6), 559-567.
  • Clarke, I. J., & Cummins, J. T. (1984). Direct pituitary effects of estrogen and progesterone on gonadotropin secretion in the ovariectomized ewe. Neuroendocrinology, 39(3), 267-274.
  • Deepika, Sh., Sanjiv, K. & Balasubramanian, N.(2018). Estrogen alpha receptor antagonists for the treatment of breast cancer: a review. Chem.cent. J. 12: 107 – 132.
  • El Wakf, A. M., Hassan, H. A., & Gharib, N. S. (2014). Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism. Cytotechnology, 66(2), 335-343.
  • El-Beshbishy, H. A. (2005). Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. Journal of Biochemistry and Molecular Biology, 38(5), 563.
  • El-Beshbishy, H. A. (2005). The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective. J Biochem Mol Biol, 38(3), 70-7.
  • El-Sheshtawy, S. M., El-Gobary, G. I., Omar, N. A., & Shawky, N. A. (2019). Ameliorating the toxic effects of cypermethrin by sesame oil in male rabbits. Slovenian Veterinary Research, 56.
  • Galigher, A.E. & Kozolof, E.N.(1964). Essential of practical microtechnique. Lea and Fabigher. Philadel. Lst.ed.
  • Gebremeskel, H., Abebe, H., Biratu, W., & Jaleto, K. (2016). Study on agronomic evaluation of tomato (lycopersicon esculentum, mill.) varieties for phonological, growth and yield characters. Current Research in Agricultural Sciences, 3(2), 22-30.
  • Guo, Y., Guo, K. J., Huang, L., Tong, X. G., & Li, X. (2004). Effect of estrogen deprivation on follicle/oocyte maturation and embryo development in mice. Chinese medical journal, 117(4), 498-502.
  • Han, X. D., Tu, Z. G., Gong, Y., Shen, S. N., Wang, X. Y., Kang, L. N., ... & Chen, J. X. (2004). The toxic effects of nonylphenol on the reproductive system of male rats. Reproductive Toxicology, 19(2), 215-221.
  • Hasan, S. A., & Abass, K. S. (2019). Prevalence of Gram Negative Bacteria Isolated from Patients with Burn Infection and their Antimicrobial Susceptibility Patterns in Kirkuk City, Iraq. Indian Journal of Public Health Research & Development, 10(8), 2197-2201.
  • Hemieda, F. A. K. E. S. (2007). Influence of gender on tamoxifen-induced biochemical changes in serum of rats. Molecular and cellular biochemistry, 301(1-2), 137-142.
  • Hussien, H. M., Abdou, H. M., & Yousef, M. I. (2013). Cypermethrin induced damage in genomic DNA and histopathological changes in brain and haematotoxicity in rats: the protective effect of sesame oil. Brain research bulletin, 92, 76-83.
  • Kanno, S., Hirano, S., & Kayama, F. (2004). Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells. Toxicology, 196(1-2), 137-145.
  • Kanu, P. J. (2011). Biochemical analysis of black and white sesame seeds from China. Am J Biochem Mol Biol, 1(2), 145-157.
  • Lasota, A., & Danowska-Klonowska, D. (2004). Experimental osteoporosis-different methods of ovariectomy in female white rats. Rocz Akad Med Bialymst, 49(Suppl 1), 129-131.
  • Laurenzana, E. M., Weis, C. C., Bryant, C. W., Newbold, R., & Delclos, K. B. (2002). Effect of dietary administration of genistein, nonylphenol or ethinyl estradiol on hepatic testosterone metabolism, cytochrome P-450 enzymes, and estrogen receptor alpha expression. Food and chemical toxicology, 40(1), 53-63.
  • Lewis, R. W., Brooks, N., Milburn, G. M., Soames, A., Stone, S., Hall, M., & Ashby, J. (2003). The effects of the phytoestrogen genistein on the postnatal development of the rat. Toxicological Sciences, 71(1), 74-83.
  • Liu, C. L., Huang, J. K., Cheng, S. P., Chang, Y. C., Lee, J. J., & Liu, T. P. (2006). Fatty liver and transaminase changes with adjuvant tamoxifen therapy. Anti-cancer drugs, 17(6), 709-713.
  • Llarena, N. C., Estevez, S. L., Tucker, S. L., & Jeruss, J. S. (2015). Impact of fertility concerns on tamoxifen initiation and persistence. JNCI: Journal of the National Cancer Institute, 107(10).
  • Luo, J. Z., & Luo, L. (2009). Ginseng on hyperglycemia: effects and mechanisms. Evidence-Based Complementary and Alternative Medicine, 6.
  • Mahmood, S. A., Amin, K. A., & Salih, S. F. (2015). Effect of acrylamide on liver and kidneys in albino wistar rats. Int J Curr Microbiol App Sci, 4(5), 434-44.
  • Masutomi, N., Shibutani, M., Takagi, H., Uneyama, C., Lee, K. Y., & Hirose, M. (2004). Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. Archives of toxicology, 78(4), 232-240.
  • Mehranjani, M. S., Abnosi, M. H., Naderi, A., & Mahmodi, M. (2007). Proteins in Rat Serum Following Treatment with p—Nonylphenol. Journal of Biological Sciences, 7(8), 1406-1411.
  • Mirabolghasemi, G., & Kamyab, Z. (2017). Changes of the uterine tissue in rats with polycystic ovary syndrome induced by estradiol valerate. International Journal of Fertility & Sterility, 11(1), 47.
  • Moshfegh, F., Baharara, J., Namvar, F., Zafar-Balanezhad, S., Amini, E., & Jafarzadeh, L. (2015). Effects of date palm pollen on fertility and development of reproductive system in female Balb/C mice. Journal of HerbMed Pharmacology, 5(1), 23-28.
  • Motrich, R. D., Ponce, A. A., & Rivero, V. E. (2007). Effect of tamoxifen treatment on the semen quality and fertility of the male rat. Fertility and sterility, 88(2), 452-461.
  • Nakari, T. (2005). Estrogenicity of phytosterols evaluated in vitro and in vivo. Environmental Sciences: an International Journal of Environmental Physiology and Toxicology, 12(2), 87-97.
  • Nasiri, A., Ziamajidi, N., Behrouj, H., Abbasalipourkabir, R., & Dehghan, A. (2014). The effects of aqueous extract of chicory root on steatosis, lipid profile and liver damage enzyme markers in tamoxifen-treated rats. Molecular and Biochemical Diagnosis Journal, 1(3), 185-194.
  • Nishino, M., Hayakawa, K., Nakamura, Y., Morimoto, T., & Mukaihara, S. (2003). Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. American Journal of Roentgenology, 180(1), 129-134.
  • Ostlund Jr, R. E., Racette, S. B., Okeke, A., & Stenson, W. F. (2002). Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. The American journal of clinical nutrition, 75(6), 1000-1004.
  • Prasanthi, K., & Rajini, P. S. (2005). Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil. Food and chemical toxicology, 43(2), 299-306.
  • Reham, S. R. (2014). Effect of nutrition supplemented with black seeds & sesame seeds with high calcium level on oesteoporsis in ovariectomized mice. Egypet. J. of Nutrition and Health Vol. 9 No 1.pp:9-17.
  • Renno, W. M., Abdeen, S., Alkhalaf, M., & Asfar, S. (2008). Effect of green tea on kidney tubules of diabetic rats. British Journal of Nutrition, 100(3), 652-659.
  • Saleh, H., Mohamed, B., & Marie, M. A. S. (2016). Sodium Butyrate Attenuates Nephrotoxicity Induced by Tamoxifen in Rats. Journal of Applied Pharmaceutical Science, 6(06), 066-072.
  • Sankar, D., Rao, M. R., Sambandam, G., & Pugalendi, K. V. (2006). Effect of sesame oil on diuretics or ß-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status. The Yale journal of biology and medicine, 79(1), 19.
  • Sever, B. (2008). Exposure to Tamoxifen During Pregnancy. Journal of the Turkish-German Gynecological Association, 9(3).
  • Siao, A. C., Hou, C. W., Kao, Y. H., & Jeng, K. C. (2015). Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer mcf-7 cells. Asian Pac J Cancer Prev, 16(9), 3779-83.
  • Soliman, M. M., Hossam, F. A.& Ghada, A. (2015).Abou EI-Ella. Genetic and histopathological alterations induced by cypermethrin in rat kidney and liver: protection by sesame oil. International Journal Of Immunopathology and Pharmacology. 28(4): 508-520.
  • Suddek, G. M. (2014). Protective role of thymoquinone against liver damage induced by tamoxifen in female rats. Canadian journal of physiology and pharmacology, 92(8), 640-644.
  • Tabassum, H., Parvez, S., Rehman, H., Dev Banerjee, B., Siemen, D., & Raisuddin, S. (2007). Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Human & experimental toxicology, 26(6), 509-518.
  • Van Meeuwen, J. A., Korthagen, N., De Jong, P. C., Piersma, A. H., & Van den Berg, M. (2007). (Anti) estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicology and applied pharmacology, 221(3), 372-383.
  • Wober, J., Weißwange, I., & Vollmer, G. (2002). Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens. The Journal of steroid biochemistry and molecular biology, 83(1-5), 227-233.
  • Zougrou, N” 92018).guessan Ernest, Blahi Adelaide Nadia, Komenen Daouda and Kouakou Koffi. Efeect of the Aqueous Extract of Cnestis Ferruginea on the Histological Structure of Female Rat Ovary and Uterine Horns. Bimedical Journal of Scientific & Technical Research. 2.(1);2073-2077.
  • Zuhair, Z. (2011). The role of vitamin C in alteration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse. Advances in Biological Chemistry, 1(02), 15.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.