Electron microscopic changes in mitochondria in central nervous system of neurotoxicity of TOCP (tri ortho cresyl phosphate) in adult hen

Abstract

The study aimed to investigate neurotoxicity of TOCP (tri ortho cresyl phosphate) of acute single dose for 21 days and sub chronic of daily doses of 90 days. All of the following mitochondria of cerebellum and midbrain, and also mitochondria of axoplasm of myelinated nerve fibers of sciatic nerve and spinal cord, showed that treatment related changes of neurotoxicity of TOCP characterized by dark stained, lamellated degenerate mitochondria. This indicated that mitochondria can be affected by the neurotoxicity of TOCP resulting in degeneration. Electron microscopic study of nervous system demonstrates very strong evidence of degeneration of mitochondria in myelinated axon. Further than presence of degenerate mitochondria even in the cytoplasm of neuron TOCP ultra-structurally showed degenerate myelin as lamellated body formation with auto phagocytosis of degeneration myelin by oligo dendrocytes. Mitochondria in axoplasm of myelinated axon in association with degenerate myelin. Morphologically degenerate mitochondria showed loss of formation of lamellated degenerate mitochondria, it neurons there was complete loss of the neuronal morphology of mitochondria, in severe cases the degeneration of mitochondria associated with calcium deposits. The presence of degeneration of mitochondria in association with neurotoxicity of TOCP indicated the serious of the damage which was caused by the TOCP.

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