Effect some of antiepileptic drugs (AEDs) on some male reproductive parameters in white rats
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 1925-1928
  • Published Online: 30 Jun 2020
  • Open Access Full Text (PDF)

Abstract

The aim of this study was to determine the effects of antiepileptic drugs (AEDs) on the sperm characteristic and some reproductive parameters in male rats. In this experiment (60) animals of male rats were divided randomly into four equal groups, Group 1: rats were treated with normal saline (0.9% NaCl) and considered as control group. Group 2: rats were treated with Phenytoin (100 mg/kg) body weight. Group 3: rats were treated with Topiramate (100 mg/kg) body weight. Group 4: rats were treated with Levetiracetam (150 mg/kg) body weight. 
The results showed a significant decrease (P <0.05) in testicular weight, total epididymal weight, prostate weight and seminal vesicle weight in G2, G3 group compared with control group. 
There was a significant decrease (p≤0.05) in serum testosterone level in all groups as compared to the control group, with no significant difference in serum FSH level and serum LH level in all groups as compared to the control group.
These results show a significant (p<0.05) decrease in the sperm count, active Sperm motility %, Viable sperm % in each treated group in comparison with control group. On the other hand, there was a significant (p<0.05) increase in abnormal sperms % in each treated group compared with control group.

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