Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 567-573
  • Published Online: 09 Mar 2020
  • Article Views: 72 | Article Download: 56
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Alabdullah SW, Alsamir SA, AlRufaei IA. Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory. Eurasia J Biosci. 2020;14(1), 567-573.

APA 6th edition
In-text citation: (Alabdullah et al., 2020)
Reference: Alabdullah, S. W., Alsamir, S. A., & AlRufaei, I. A. (2020). Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory. Eurasian Journal of Biosciences, 14(1), 567-573.

Chicago
In-text citation: (Alabdullah et al., 2020)
Reference: Alabdullah, Sundus W., Shaimaa A. Alsamir, and Iqbal A. AlRufaei. "Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory". Eurasian Journal of Biosciences 2020 14 no. 1 (2020): 567-573.

Harvard
In-text citation: (Alabdullah et al., 2020)
Reference: Alabdullah, S. W., Alsamir, S. A., and AlRufaei, I. A. (2020). Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory. Eurasian Journal of Biosciences, 14(1), pp. 567-573.

MLA
In-text citation: (Alabdullah et al., 2020)
Reference: Alabdullah, Sundus W. et al. "Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory". Eurasian Journal of Biosciences, vol. 14, no. 1, 2020, pp. 567-573.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Alabdullah SW, Alsamir SA, AlRufaei IA. Effect of Thymoquinone on some biochemical and hormonal indices and their protective effect on the genital organs of rats after cancer induction in Laboratory. Eurasia J Biosci. 2020;14(1):567-3.

Abstract

The aim of this study is to demonstrate the importance of Thymoquinone as a treatment for cancer tumors and to indicate whether it has a negative effect on the male genital organs. For this purpose, 18 adult males of white rats were divided into three groups (A: control group, B: group treated with carcinogen (AOM) only, C: group treated with Thymoquinone after treatment with carcinogen (TQ+AOM)). Each group included six rats and induced colorectal cancer. By injecting Azoxymethane (AOM) once a week for groups B, C except group A was considered as a control group. The tumor was detected by examining the tissue in the AOM-injected groups compared to the control group and CEA concentration. Group treated by TQ obsorbed decreased in CEA concentration was response to the treatment used. The weights of the animals and genital organs were measured before and after the experiment where the carcinogen caused weight changes compared to the control group while the TQ did not show changes in the weight of animals and is evidence of resistance to this substance of oxidative stress due to carcinogens, also been conducted some tests for testicular functions such as measurement of the concentration of testosterone hormone, serum acid phosphatase and concentration of sperm living has been observed significant differences (P <0.05) between these totals and for all tests. Amicroscopic examination of the sperm forms was performed notice the distortions in the sperm in AOM group, while TQ group these abnormalities were not observed. The histomicroscopic examination of the testicular, prostate gland and seminal vesicle by using light microscopy for all rats showed pathological changes in the group treated with AOM such as sperm cell degeneration , appearance of sperm ghosts, breakdown of the walls the Hyperplasia, and presence dermal infiltrating glandular cavities, infiltration Inflammatory cells around the Hyperplasia, while the TQ group showed no effect on these tissues. The current study aimed at showing the effect of TQ which is an antioxidant on the proliferative system and used as a treatment for tumors without causing any side effects on this tissue.

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