Effect of the protein mixture based on dry mare’s milk on the state of antioxidant defense system and lipid peroxidation of membranes under small doses of lead affecting a body


The article reviews the state of antioxidant system, in the setting of exposure to lead acetate, the daily consumption of a protein mixture based on mare’s milk has contributed to increased urinary excretion of lead and a decrease in its level in blood plasma.
Also, on the 60th day of the protein mixture intake, a positive dynamics of antioxidant status was noted, expressed in a decrease in the MDA and diene conjugates level in the blood red-cells membranes compared to the control variant by 56.4% and 43.75%, respectively, as well as an increase in the total antioxidant activity by 34.35%, the activity of key enzymes of the antioxidant system – superoxide dismutase by 63.37% and catalase by 89.58%. A similar pattern was observed in liver microsomes: on the 60th day of the protein mixture intake, the MDA level has decreased from (0.52±0.03) nmol/mg of protein to (0.28±0.01) nmol/mg of protein, diene conjugates – from (1.6±0.8) nmol/mg of protein to (0.85±0.05) nmol/mg of protein, and the total antioxidant activity, the activity of superoxide dismutase and catalase have increased by 17.48%, 11.34 nmol/mg of protein and 9.75 nmol/mg protein, respectively. 
The beneficial effect of the protein mixture on the phospholipid composition of membranes and decrease in their viscosity and stiffness was noted in the setting of toxic exposure to lead acetate.
The changes justify the feasibility of using the protein mixture as a means of reducing the toxic load of lead compounds on the body.


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