The pollutants are the effective factors of the presence and spread of aquatic organisms, and the haematological and hormonal parameters are the most common stress indicatorsthat can estimated the fish health. In the present study, some chemical and physical parameters were analyzed from two stations in Basrah province, from Marine Science Centre tanks –BasrahUniversity and the other station in Al-HababaRiver in AbuAl-Khasseebdistrict. An attempt has been made to study the effect of pollutant stressors on haematological [red blood cell count (RBCs), haemoglobin (Hb), packed cell volume (PCV), white blood cell count (WBC) and differential leucocyte count (DLC)] and hormonal (TSH, T3, T4, testosterone, cortisol and glucose) parameters of two types of fish Tilapiazillii and Cyprinuscarpio. Under the effect of natural stressors, pysico-chemical factors were found to exhibit significant decline in RBC, Hb, PCV and WBCs. DLC when viewed revealed a decrease in lymphocytes, monocytes, eosinophils and basophils whereas neutrophils and thrombocytes exhibited rather an appreciable increase. A significant increase (P ≤ 0.05) cortisol and glucose levels were observed up. Tilapiazillii and Cyprinuscarpio also depicted significant decline in TEC, Hb and Hct under the effect of phosphate (6.05 mg/l). TLC depicted significant increase and among Differential leucocyte count (DLC) lymphocytes, monocytes and eosinophils register an increase but neutrophils, basophils and thrombocyte counts exhibit a decline in their numbers, also Cortisol and glucose levels were noticed to increase. Generally, C. carpio was more affected than T.zillii regarding haematological, biochemical indicators and histopathological examinations.

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