Abstract

Introduction: Radical Hysterectomy and Pelvic Lymph-Node Dissection (RH-PLND), with or without Neoadjuvant Chemotherapy (NAC) nor Adjuvant Therapy (AT), is still the treatment of choice in stages IB-IIB of cervical cancer due to limited access to concurrent chemoradiotherapy. This study aimed to find out the 3-year Disease-Free Survival (DFS) and Overall Survival (OS) in post-RH-PLND for cervical cancer patients.
Methods: This was a restrospective descriptive observational study. Sample was divided into 4 groups [group 1: RH-PLND and group 2: RH-PLND + AT (operable group); group 3: NAC + RH-PLND + AT and group 4: NAC + RH-PLND (inoperable group)].
Results: Total of eight recurrences and six mortalities, with the highest 3-years DFS and OS in group 2 (91.7%) and 1 (100%), respectively. Group 3 had the lowest 3-years DFS and OS compared to other groups (67.4 and 65.6%, respectively). Most recurrence and mortality occured in the inoperable group (five and four patients).
Conclusion: The highest DFS and OS among all groups was post RH-PLND cervical cancer patients who get adjuvant therapy group and post-RH-PLND without parametric infiltration pre-operation and positive prognosis factors group, respectively.

References

  • Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP (2017/March) The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA: A Cancer Journal for Clinicians. United States https://doi.org/10.3322/caac.21388
  • Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, Amunni G, Raspagliesi F, Zola P, Mangioni C, Landoni F (2002) Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20(1): 179-188. https://doi.org/10.1200/JCO.2002.20.1.179
  • Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, Abdel-Rahman O, et al. (2019) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. JAMA Oncology 5(12): 1749-1768. https://doi.org/10.1001/jamaoncol.2019.2996
  • Frederick P, Whitworth J, Alvarez R (2009) Radical hysterectomy for carcinoma of the uterine cervix. The Global Library of Women’s Medicine.
  • Jafarzadeh M, Mousavizadeh K, Joghataei MT, Hashemi Bahremani M, Safa M, Asghari SMA (2018) Fibroblast Growth Factor Antagonist Peptide Inhibits Breast Cancer in BALB/c Mice , 13(1): 348-354.
  • Hafiz M, Mulawardhana P and Kurniasari N (2019) Profil Penderita Karsinoma Serviks di Departemen/SMF Patologi Anatomi RSUD Dr. Soetomo Periode 2010-2013. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga 9(1): 49-53.
  • Harrington KJ and Thomas H (1997) Radical surgery versus radiotherapy for stage Ib-lla cervical cancer. The Lancet 350(9085): 1179.
  • Hoffman MS (2004) Extent of radical hysterectomy: evolving emphasis. Gynecologic oncology 94(1): 1-9. https://doi.org/10.1016/j.ygyno.2004.05.025
  • Kokka F, Bryant A, Brockbank E, Powell M and Oram D (2015) Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. Cochrane Database of Systematic Reviews (4).
  • Landoni F, Colombo A, Milani R, Placa F, Zanagnolo V and Mangioni C (2017) Randomized study between radical surgery and radiotherapy for the treatment of stage IB-IIA cervical cancer: 20-year update. Journal of gynecologic oncology 28(3).
  • Lee J-Y, Kim YT, Kim S, Lee B, Lim MC, Kim J-W and Won Y-J (2015) Prognosis of Cervical Cancer in the Era of Concurrent Chemoradiation from National Database in Korea: A Comparison between Squamous Cell Carcinoma and Adenocarcinoma. PloS one 10(12): e0144887. https://doi.org/10.1371/journal.pone.0144887
  • Liu S-P, Yang J-X, Cao D-Y and Shen K (2013) Analysis of 30 patients with persistent or recurrent squamous cell carcinoma of the cervix within one year after concurrent chemoradiotherapy. Cancer biology & medicine 10(4): 227-231. https://doi.org/10.7497/j.issn.2095-3941.2013.04.007
  • Marchiolè P, Buénerd A, Benchaib M, Nezhat K, Dargent D and Mathevet P (2005) Clinical significance of lympho vascular space involvement and lymph node micrometastases in early-stage cervical cancer: a retrospective case-control surgico-pathological study. Gynecologic oncology 97(3): 727-732.
  • Mohiuddin AK (2019) Chemical Contaminants and Pollutants in the Measurable Life of Dhaka City. European Journal of Sustainable Development Research, 3(2): em0083. https://doi.org/10.29333/ejosdr/5727
  • Mursyidah NI, Ashariati A and Kusumastuti EH (2019) Comparison of Breast Cancer 3-years Survival Rate Based on the Pathological Stages. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga 10(1): 38-43.
  • Pasaribu HP, Lubis LI, Dina S, Simanjuntak RY, Siregar HS and Rivany R (2018) Difference of protein 53 expression based on radiation therapy response in cervical cancer. Vol. 125. Institute of Physics Publishing https://doi.org/10.1088/1755-1315/125/1/012190
  • Peters III WA, Liu PY, Barrett RJ, Stock RJ, Monk BJ, Berek JS, Souhami L, Grigsby P, Gordon Jr W and Alberts DS (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. Obstetrical & Gynecological Survey 55(8): 491-492.
  • Razak A, Maidin MA, Tamar M and Zuardin (2018) Economic burden of cancer patients at hasanuddin university teaching hospital, Makassar: A qualitative study. Indian Journal of Public Health Research and Development 9(12): 1438-1443. https://doi.org/10.5958/0976-5506.2018.02055.7
  • Rogers L, Siu SSN, Luesley D, Bryant A and Dickinson HO (2012) Radiotherapy and chemoradiation after surgery for early cervical cancer. The Cochrane database of systematic reviews 5(5): CD007583. https://doi.org/10.1002/14651858.CD007583.pub3
  • Rydzewska L, Tierney J, Vale CL and Symonds PR (2012) Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. The Cochrane database of systematic reviews 12(12): CD007406. https://doi.org/10.1002/14651858.CD007406.pub3
  • Sevin BU, Lu Y, Bloch DA, Nadji M, Koechli OR and Averette HE (1996) Surgically defined prognostic parameters in patients with early cervical carcinoma. A multivariate survival tree analysis. Cancer 78(7): 1438-1446. https://doi.org/10.1002/(SICI)1097-0142(19961001)78:7<1438::AID-CNCR10>3.0.CO;2-0
  • Shen Y, Yang L and Wang Z (2012) Treatment of early bulky cervical cancer with neoadjuvant paclitaxel, carboplatin and cisplatin prior to laparoscopical radical hysterectomy and pelvic lymphadenectomy. Oncology letters 3(3): 641-645. https://doi.org/10.3892/ol.2011.529
  • Sherris J, Herdman C and Elias C (2001) Beyond our borders: cervical cancer in the developing world. Western Journal of Medicine 175(4): 231
  • Siegel R, Ma J, Zou Z and Jemal A (2014) Cancer statistics, 2014. CA: a cancer journal for clinicians 64(1): 9-29. https://doi.org/10.3322/caac.21208
  • Singh N and Arif S (2004) Histopathologic parameters of prognosis in cervical cancer--a review. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 14(5): 741-750. https://doi.org/10.1111/j.1048-891X.2004.014504.x
  • Surbakti E, Santosa H, Padang N and Rochadi K (2018) The influence of empowerment of women of childbearing age on cervical cancer prevention behavior. Giornale Italiano di Ostetricia e Ginecologia 40(2): 53-60
  • Torre LA, Bray F, Siegel RL and Ferlay J (2015) Global Cancer Statistics , 2012. Ca Cancer J Clin 65(2): 87-108. https://doi.org/10.3322/caac.21262
  • Wiebe E, Denny L and Thomas G (2012) Cancer of the cervix uteri. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 119 Suppl: S100-9. https://doi.org/10.1016/S0020-7292(12)60023-X
  • Zreik TG, Chambers JT and Chambers SK (1996) Parametrial involvement, regardless of nodal status: a poor prognostic factor for cervical cancer. Obstetrics and gynecology 87(5 Pt 1): 741-746. https://doi.org/10.1016/0029-7844(96)00026-9
  • Zulham, Jusuf AA, Indarti J and Lisnawati (2011) Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process. Sains Malaysiana 40(5): 475-479.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.