Introduction: Radical Hysterectomy and Pelvic Lymph-Node Dissection (RH-PLND), with or without Neoadjuvant Chemotherapy (NAC) nor Adjuvant Therapy (AT), is still the treatment of choice in stages IB-IIB of cervical cancer due to limited access to concurrent chemoradiotherapy. This study aimed to find out the 3-year Disease-Free Survival (DFS) and Overall Survival (OS) in post-RH-PLND for cervical cancer patients.
Methods: This was a restrospective descriptive observational study. Sample was divided into 4 groups [group 1: RH-PLND and group 2: RH-PLND + AT (operable group); group 3: NAC + RH-PLND + AT and group 4: NAC + RH-PLND (inoperable group)].
Results: Total of eight recurrences and six mortalities, with the highest 3-years DFS and OS in group 2 (91.7%) and 1 (100%), respectively. Group 3 had the lowest 3-years DFS and OS compared to other groups (67.4 and 65.6%, respectively). Most recurrence and mortality occured in the inoperable group (five and four patients).
Conclusion: The highest DFS and OS among all groups was post RH-PLND cervical cancer patients who get adjuvant therapy group and post-RH-PLND without parametric infiltration pre-operation and positive prognosis factors group, respectively.


  • Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP (2017/March) The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA: A Cancer Journal for Clinicians. United States https://doi.org/10.3322/caac.21388
  • Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, Amunni G, Raspagliesi F, Zola P, Mangioni C, Landoni F (2002) Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20(1): 179-188. https://doi.org/10.1200/JCO.2002.20.1.179
  • Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, Abdel-Rahman O, et al. (2019) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. JAMA Oncology 5(12): 1749-1768. https://doi.org/10.1001/jamaoncol.2019.2996
  • Frederick P, Whitworth J, Alvarez R (2009) Radical hysterectomy for carcinoma of the uterine cervix. The Global Library of Women’s Medicine.
  • Jafarzadeh M, Mousavizadeh K, Joghataei MT, Hashemi Bahremani M, Safa M, Asghari SMA (2018) Fibroblast Growth Factor Antagonist Peptide Inhibits Breast Cancer in BALB/c Mice , 13(1): 348-354.
  • Hafiz M, Mulawardhana P and Kurniasari N (2019) Profil Penderita Karsinoma Serviks di Departemen/SMF Patologi Anatomi RSUD Dr. Soetomo Periode 2010-2013. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga 9(1): 49-53.
  • Harrington KJ and Thomas H (1997) Radical surgery versus radiotherapy for stage Ib-lla cervical cancer. The Lancet 350(9085): 1179.
  • Hoffman MS (2004) Extent of radical hysterectomy: evolving emphasis. Gynecologic oncology 94(1): 1-9. https://doi.org/10.1016/j.ygyno.2004.05.025
  • Kokka F, Bryant A, Brockbank E, Powell M and Oram D (2015) Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. Cochrane Database of Systematic Reviews (4).
  • Landoni F, Colombo A, Milani R, Placa F, Zanagnolo V and Mangioni C (2017) Randomized study between radical surgery and radiotherapy for the treatment of stage IB-IIA cervical cancer: 20-year update. Journal of gynecologic oncology 28(3).
  • Lee J-Y, Kim YT, Kim S, Lee B, Lim MC, Kim J-W and Won Y-J (2015) Prognosis of Cervical Cancer in the Era of Concurrent Chemoradiation from National Database in Korea: A Comparison between Squamous Cell Carcinoma and Adenocarcinoma. PloS one 10(12): e0144887. https://doi.org/10.1371/journal.pone.0144887
  • Liu S-P, Yang J-X, Cao D-Y and Shen K (2013) Analysis of 30 patients with persistent or recurrent squamous cell carcinoma of the cervix within one year after concurrent chemoradiotherapy. Cancer biology & medicine 10(4): 227-231. https://doi.org/10.7497/j.issn.2095-3941.2013.04.007
  • Marchiolè P, Buénerd A, Benchaib M, Nezhat K, Dargent D and Mathevet P (2005) Clinical significance of lympho vascular space involvement and lymph node micrometastases in early-stage cervical cancer: a retrospective case-control surgico-pathological study. Gynecologic oncology 97(3): 727-732.
  • Mohiuddin AK (2019) Chemical Contaminants and Pollutants in the Measurable Life of Dhaka City. European Journal of Sustainable Development Research, 3(2): em0083. https://doi.org/10.29333/ejosdr/5727
  • Mursyidah NI, Ashariati A and Kusumastuti EH (2019) Comparison of Breast Cancer 3-years Survival Rate Based on the Pathological Stages. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga 10(1): 38-43.
  • Pasaribu HP, Lubis LI, Dina S, Simanjuntak RY, Siregar HS and Rivany R (2018) Difference of protein 53 expression based on radiation therapy response in cervical cancer. Vol. 125. Institute of Physics Publishing https://doi.org/10.1088/1755-1315/125/1/012190
  • Peters III WA, Liu PY, Barrett RJ, Stock RJ, Monk BJ, Berek JS, Souhami L, Grigsby P, Gordon Jr W and Alberts DS (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. Obstetrical & Gynecological Survey 55(8): 491-492.
  • Razak A, Maidin MA, Tamar M and Zuardin (2018) Economic burden of cancer patients at hasanuddin university teaching hospital, Makassar: A qualitative study. Indian Journal of Public Health Research and Development 9(12): 1438-1443. https://doi.org/10.5958/0976-5506.2018.02055.7
  • Rogers L, Siu SSN, Luesley D, Bryant A and Dickinson HO (2012) Radiotherapy and chemoradiation after surgery for early cervical cancer. The Cochrane database of systematic reviews 5(5): CD007583. https://doi.org/10.1002/14651858.CD007583.pub3
  • Rydzewska L, Tierney J, Vale CL and Symonds PR (2012) Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. The Cochrane database of systematic reviews 12(12): CD007406. https://doi.org/10.1002/14651858.CD007406.pub3
  • Sevin BU, Lu Y, Bloch DA, Nadji M, Koechli OR and Averette HE (1996) Surgically defined prognostic parameters in patients with early cervical carcinoma. A multivariate survival tree analysis. Cancer 78(7): 1438-1446. https://doi.org/10.1002/(SICI)1097-0142(19961001)78:7<1438::AID-CNCR10>3.0.CO;2-0
  • Shen Y, Yang L and Wang Z (2012) Treatment of early bulky cervical cancer with neoadjuvant paclitaxel, carboplatin and cisplatin prior to laparoscopical radical hysterectomy and pelvic lymphadenectomy. Oncology letters 3(3): 641-645. https://doi.org/10.3892/ol.2011.529
  • Sherris J, Herdman C and Elias C (2001) Beyond our borders: cervical cancer in the developing world. Western Journal of Medicine 175(4): 231
  • Siegel R, Ma J, Zou Z and Jemal A (2014) Cancer statistics, 2014. CA: a cancer journal for clinicians 64(1): 9-29. https://doi.org/10.3322/caac.21208
  • Singh N and Arif S (2004) Histopathologic parameters of prognosis in cervical cancer--a review. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 14(5): 741-750. https://doi.org/10.1111/j.1048-891X.2004.014504.x
  • Surbakti E, Santosa H, Padang N and Rochadi K (2018) The influence of empowerment of women of childbearing age on cervical cancer prevention behavior. Giornale Italiano di Ostetricia e Ginecologia 40(2): 53-60
  • Torre LA, Bray F, Siegel RL and Ferlay J (2015) Global Cancer Statistics , 2012. Ca Cancer J Clin 65(2): 87-108. https://doi.org/10.3322/caac.21262
  • Wiebe E, Denny L and Thomas G (2012) Cancer of the cervix uteri. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 119 Suppl: S100-9. https://doi.org/10.1016/S0020-7292(12)60023-X
  • Zreik TG, Chambers JT and Chambers SK (1996) Parametrial involvement, regardless of nodal status: a poor prognostic factor for cervical cancer. Obstetrics and gynecology 87(5 Pt 1): 741-746. https://doi.org/10.1016/0029-7844(96)00026-9
  • Zulham, Jusuf AA, Indarti J and Lisnawati (2011) Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process. Sains Malaysiana 40(5): 475-479.


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