Background and aim: The aim of present Systematic Review and Meta-analysis was determine the relation between the prosthesis and splinting of the implant differences.
Method: From the electronic databases, PubMed, Cochrane Library, Embase, ISI have been used to perform a systematic literature between 2015 and 2020. Therefore, a software program (Endnote X8) has been utilized for managing the electronic titles. Searches were performed with mesh terms. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included. Moreover, mean differences between two groups (Immediate Loading and Delayed Loading) with 95% confidence interval (CI), fixed effect model and Inverse-variance method and Odds ratio between two groups (Immediate Loading and Delayed Loading) with 95% confidence interval (CI), fixed effect model and Mantel-Haenszel were calculated. Random effects were used to deal with potential heterogeneity and I2 showed heterogeneity. The Meta analysis and forest plots have been evaluated with the use of a software program available in the market (i.e., Comprehensive Meta-Analysis Stata V16).
Result: A total of 243 potentially relevant titles and abstracts were found during the electronic and manual search. Finally, a total of three publications fulfilled the inclusion criteria required for this systematic review. Mean difference of Crestal bone loss was (MD, -0.29 95% CI -0.54, -0.04. P= 0.02), and Odds ratio of Implant loss was (OR, -1.91 95% CI -3.44, -0.38. P= 0.01) among 3 studies.
Conclusion: The present study shows to implant loss, there was statistically significant difference between immediate loading and delayed loading, and delayed loading is preferred to removable prostheses.


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