Correlation between interleukin-10 and interleukin-12 levels with systemic lupus erythematosus and the effect of the age and gender

Abstract

Background: Systemic Lupus Erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems. Family physicians should be familiar with the manifestations of lupus to aid in early diagnosis, monitoring patients with mild disease, recognizing warning signs that require referral to a rheumatologist, and helping to monitor disease activity and treatment in patients with moderate to severe disease.
Materials & Methods: The study included 70 samples included: 50 outpatients who attended to Al-Hilla General Teaching Hospital in Babylon Governorate who are suffering from dermatitis during the period (Feb.2019 to Aug. 2019). Their ages are ranging between (1-45) years old and from both genders. Depending on the age, the patients were divided into three groups included 1-15 years old, 16-30 years old and 31-45 years old. The negative control group included 20 healthy persons in the same age groups. A questionnaire was done to obtain the required information from the patient for the purpose of statistical analyzes.
Results: A significant difference in the level of IL-10 & IL-12 were detected in patient groups in comparison with the control group. The results also showed that O+ blood group is the most frequent (30%) among patient groups. Furthermore, there is a genetic tendency in the frequency of onset of Systemic Lupus Erythematosus and the family history: 20%, 40%,and 30%of patients with SLE have family history of this disease in both parents, in mother only, in father only, respectively. Results also showed that the frequency of Systemic Lupus Erythematosus infection was effected by the gender (female is more vulnerable) and the age (31-45 years old has highest frequency).

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