Axonal sensory motor polyneuropathy as novel initial manifestation of POEMS syndrome: Case report
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 1415-1418
  • Published Online: 29 Jun 2020
  • Open Access Full Text (PDF)


Para-proteinemic Peripheral neuropathy can be a part of a multi-systemic disease like POEMS syndrome. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome driven by plasma cell dyscrasias. We report a diabetic patient with novel manifestation of axonal sensory motor polyneuropathy. Other favorable findings for fulfilling the known criteria of POEMS syndrome in our patient were skin pigmentation, splenomegaly, indeterminate SPEP with evidence of paraproteinemia in serum immunefixation and multiple sclerolytic lesions in vertebral. Our case highlights the complex nature of this multi-system syndrome and the diagnostic challenges posed by this disease, the potential effects of delayed diagnosis and the importance of an integrated sub-specialty approach to management.


  • Abrisqueta P, Rovira M, Cibeira MT, Vallansot R, Gutiérrez G, et al. (2007) Autologous haematopoietic stem cell transplantation in POEMS syndrome: results in 4 cases. Med Clin (Barc). 129(15):578-81.
  • Arana C, Pérez de León JA, Gómez-Moreno G, Pérez-Cano R, Martín Hernández T (2015) POEMS Syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy and Skin Changes) Treated with Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review. Am J Case Rep. 16:124-9.
  • Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL (1980) Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: The POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore). 59(4):311-22.
  • Cui RT, Huang XS, Shi Q, Tian CL, Liu JX, Pu CQ (2011) POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes) syndrome in China. Intern Med J. 41(6):481-5.
  • Dispenzieri A (2007) POEMS syndrome. Blood Rev. 21(6):285-99.
  • Dispenzieri A (2015) POEMS syndrome: update on diagnosis, risk-stratification, and management. Am J Hematol. 90(10):951-62.
  • Dispenzieri A, Buadi FK (2013) A review of POEMS syndrome. Oncology (Williston Park), 27: 1242-50.
  • Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR (2003) POEMS syndrome: defnitions and long-term outcome. Blood. 101(7):2496-506.
  • Glavey SV, Leung N (2016) Monoclonal gammopathy: The good, the bad and the ugly. Blood Rev. 30(3):223-31.
  • Ji ZF, Zhang DY, Weng SQ, Shen XZ, Liu HY, Dong L (2012) POEMS syndrome: a report of 14 cases and review of the literature. ISRN Gastroenterol. 2012:584287.
  • Katzmann JA, Kyle RA, Benson J, Larson DR, Snyder MR, Lust JA (2009) Screening panels for detection of monoclonal gammopathies. Clin Chem. 55: 1517-22
  • Kwan JY (2007) Paraproteinemic neuropathy. Neurol Clin. 25(1):47-69.
  • Rajabally YA (2011) Neuropathy and paraproteins: review of a complex association. Eur J Neurol. 18(11):1291-8.
  • Rojas-Garcia R, Gallardo E, Illa I (2013) Paraproteinemic neuropathies. Presse medicale (Paris, France: 1983). 42(6 Pt 2): e225-34.
  • Shiberu T, Ashagere H, Negeri M (2014) Effect of Some Botanicals against Termites, Macroterms Spp.(Isoptera: Termitidae) Under Laboratory Conditions. International Journal of Sustainable Agricultural Research, 1(2): 52-57.
  • Zivkovic SA, Lacomis D, Lentzsch S (2009) Paraproteinemic neuropathy. Leuk Lymphoma. 50(9):1422-33.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.