Axonal sensory motor polyneuropathy as novel initial manifestation of POEMS syndrome: Case report
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 1415-1418
  • Published Online: 29 Jun 2020
  • Open Access Full Text (PDF)

Abstract

Para-proteinemic Peripheral neuropathy can be a part of a multi-systemic disease like POEMS syndrome. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome driven by plasma cell dyscrasias. We report a diabetic patient with novel manifestation of axonal sensory motor polyneuropathy. Other favorable findings for fulfilling the known criteria of POEMS syndrome in our patient were skin pigmentation, splenomegaly, indeterminate SPEP with evidence of paraproteinemia in serum immunefixation and multiple sclerolytic lesions in vertebral. Our case highlights the complex nature of this multi-system syndrome and the diagnostic challenges posed by this disease, the potential effects of delayed diagnosis and the importance of an integrated sub-specialty approach to management.

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