Treating herbl medicines, based on their long-term widespread use as anti-fertility agents, conversely it`s possible to have herbs that are effective for improving fertility. Endometrium of the uterus undergoes enormous renovation in response to systemic changes in reproductive hormones (progesterone and estradiol) during each reproductive cycle).Twenty five health mature female mice (aged 8 weeks) divided into five groups (5/each) were participants in the current to investigate the fertility effects of Origanum vulgare against the reproductive toxicity induced by Fenugreek. These effects examine by measuring the number of ovarian follicles, thickness of the uterus and steroid hormone levels (estrogen & progesterone) in serum. The results showed no significant differences (p>0.05) in number of ovarian follicales, steroid hormones level, and lower in thikness layers of uterus tissus the experimental treated groups with Fenugreek (250 mg/kg and O.vulgare (90,180,270) mg/kg respectively. Depending on these outcomes, the hot aqueous of O. vulgare has enhancement reproductive system in female albino mice, and these results give additional scientific support to maybe use O. vulgare as an alternative for problems of fertility.


  • Abasian Z, Rostamzadeh A, Mohammadi M, Hosseini M, Rafieian-kopaei M (2018) A review on role of medicinal plants in polycystic ovarian syndrome: Pathophysiology, neuroendocrine signaling, therapeutic status and future prospects. Middle East Fertil Soc J 23: 255-262.
  • Bano D, Tabassum H, Ahmad A, Mabood A, Ahmad I (2016) The medicinal significance of the bioactive compounds of trigonella foenum-graecum: A review. Int J Res Ayurveda Pharm 7: 84-91.
  • Ben Hameid AS, Al-Sindi TA, Allow AK, Nafie EM, Alahmad BE, Faisal GG (2019) Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model. Oman Med J 34: 238-243.
  • Brogi H, Elbachir H, Amrani N El, Amsaguine S, Radallah D (2019) Fenugreek seeds estrogenic activity in ovariectomized female rats. Curr Issues Pharm Med Sci 32: 138-145.
  • Darbre PD (2015) What Are Endocrine Disrupters and Where Are They Found? Endocr Disrupt Hum Heal: 3-26.
  • Dragoeva AP, Koleva VP, Nanova ZD, Kaschieva MZ (2014) Allelopathy of Cold Water Extracts from Origanum vulgare ssp. vulgare L. J Agric Chem Environ 03: 144-150.
  • ElSawy NA, Hadda TB, Bakr E-SH, Header EA, Fakim AG, Mabkhot YN, et al. (2014) Effects of Crude Aqueous Extract of Origanum vulgaris in Developing Ovary of Rabbits Following in Utero, Adolescent, and Postpubertal Exposure. Vedic Res Int Phytomedicine 2: 73.
  • Hilles A, Allow A, Mahmood S (2016) Evaluation and comparison of the antifertility potential activity and adverse effects of Trigonella foenum-graecum seeds and combined oral contraceptive pills in female rats. Int J Reprod Contraception, Obstet Gynecol 5: 680-688.
  • Khalki L, M’hamed SB, Bennis M, Chait A, Sokar Z (2010) Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2010.06.033
  • Khan A, Bashir S, Khan SR, Gilani AH (2011) Antiurolithic activity of Origanum vulgare is mediated through multiple pathways. BMC Complement Altern Med 11: 96.
  • Khazaei M, Montaseri A, Khazaei MR, Khanahmadi M (2011) Study of Foeniculum vulgare Effect on Folliculogenesis in Female Mice. Int J Fertil Steril 5: 122-127.
  • Kheirandish R, Abshenas J, Sakhaee E, Azizi S, Aghaabbasi S (2018) Effects of Origanum vulgare on morphometric and histopathologic of ovary following long-term administration of copper. J Anim Res (Iranian J Biol 31: 85-96.
  • Kumar D, Singhal A, Bansal S, Gupta S (2015) Extraction, isolation and evaluation Trigonella foenum-graecum as mucoadhesive agent for nasal gel drug delivery. J Nepal Pharm Assoc 27: 40-45.
  • Kushi AG Al (2019) The Effect of the Aqueous Extract of Origanum vulgare on the Postnatal Development of the Rat Prostate. Pakistan J Nutr 18: 930-935.
  • Kyoji Yoshino, Naoki Higashi KK (2006) Antioxidant and Antiinflammatory Activities of Oregano Extract. J Heal Sci 528501: 169-173.
  • Mensah OS, Jincai Z, Isaac AB, Patrick A (2017) The Role of Institutional Policies in Promoting Agribusiness Development in Rural China. Agriculture and Food Sciences Research, 4(2): 37-44.
  • Modaresi M, Mahdian B, Jalalizand A (2012) The Effect of Hydro-Alcoholic Extract of Fenugreek Seeds on Female Reproductive Hormones in Mice. Int Conf Appl Life Sci: 437-443.
  • Oniga I, Pus C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, Marica R, et al. (2018) Origanum vulgare ssp. vulgare: Chemical composition and biological studies. Molecules 23. https://doi.org/10.3390/molecules23082077
  • Saad B, Said O (2011) Greco-Arab and Islamic Herbal Medicine: Traditional System, Ethics, Safety, Efficacy, and Regulatory Issues. https://doi.org/10.1002/9780470944363
  • Scheer Bing R, Peixoto da Silva Mello F, Larissa Schuch T, Regina Alves Rodrigues M, Bastos de Mello F, Roberto Braga de Mello J (2015) Reproductive Toxicity Assessment of Origanum vulgare Essential Oil on Male Wistar Rats. Acta Sci Vet 43: 1-7.
  • Yoshino K, Higashi N, Koga K (2006) Antioxidant and antiinflammatory activities of oregano extract. J Heal Sci 52: 169-173.


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