Anti-fungal activity for some nanoparticles against some yeast and mold strain


The present research aim to determine the activity of some antifungal nanoparticles against some molds and yeast strains since Nanoparticles are of wide use in medical field as antimicrobial agents and many promised results show that’s it’s could be suitable for human use with low concentration and these includes multiple metal oxides such as yttrium, copper, nickel, zinc, iron and silver that have antimicrobial activity, in this research we test the antifungal activity of some nanoparticles (NPs) against different strains of mold and yeast. Antimicrobial activity of NPs was accomplished by the mean of disk diffusion assay using dilutions of (200, 100, 50, 25, and 12.5) and the MIC and MFC of each isolate is well as antibiotic discs were acquired in order to compare its antifungal activity within NPs activity,and those antibiotic include Amikacin (AK30), Cefotaxime(CX30), Ciprofloxacin(CPR5), Gentamicin(CN10). The results show that zinc oxide, ferric oxide, cupper oxide, silver and yittrium nanoparticles have no anti-fungal activity against tested fungi, while there was different inhibitory effect of antibiotics against the selected fungal strain and the KCA antibiotic appeared with the highest activity while the FLU appeared with the least that its concluded that using NPs as an economic alternative anti-fungal medicine especially in treating ectopic infections must be with high concentration since low concentration give no result without taking risk of developing resistant fungal strains as with antibiotics, as well as to use lab animals for most accurate results.


  • Alnasrawi, T. H., Althabet, Z. A., Salih, G. S., & Al-Jassani, M. J. (2019). Antibacterial Activity of Some Nanoparticles Against Some Pathogenic Bacteria That Isolated From Urinary Tract Infections Patient. International Journal of Drug Delivery Technology, 9(04), 682-685.
  • Amichai, B., & Grunwald, M. H. (1998). Adverse drug reactions of the new oral antifungal agents–terbinafine, fluconazole, and itraconazole. International journal of dermatology, 37(6), 410-415.
  • Chan, S. (2012). Instantaneous biosynthesis of silver nanoparticles (AgNPs) by selected macro fungi. Australian journal of basic and applied sciences, 6(1), 222-226.
  • Costa, C. S., Ronconi, J. V. V., Daufenbach, J. F., Gonçalves, C. L., Rezin, G. T., Streck, E. L., & da Silva Paula, M. M. (2010). In vitro effects of silver nanoparticles on the mitochondrial respiratory chain. Molecular and cellular biochemistry, 342(1-2), 51-56.
  • García‐Contreras, R., Argueta‐Figueroa, L., Mejía‐Rubalcava, C., Jiménez‐Martínez, R., Cuevas‐Guajardo, S., Sánchez‐Reyna, P. A., & Mendieta‐Zeron, H. (2011). Perspectives for the use of silver nanoparticles in dental practice. International dental journal, 61(6), 297-301.
  • Hartsel, S., & Bolard, J. (1996). Amphotericin B: new life for an old drug. Trends in pharmacological sciences, 17(12), 445-449.
  • Iravani, S. (2011). Green synthesis of metal nanoparticles using plants. Green Chemistry, 13(10), 2638-2650.
  • Jones, S. A., Bowler, P. G., Walker, M., & Parsons, D. (2004). Controlling wound bioburden with a novel silver‐containing Hydrofiber® dressing. Wound repair and regeneration, 12(3), 288-294.
  • Karbasian, M., Atyabi, S. M., Siadat, S. D., Momen, S. B., & Norouzian, D. (2008). Optimizing nano-silver formation by Fusarium oxysporum PTCC 5115 employing response surface methodology. American journal of Agricultural and biological science.
  • Kashyap, P. L., Kumar, S., Srivastava, A. K., & Sharma, A. K. (2013). Myconanotechnology in agriculture: a perspective. World Journal of Microbiology and Biotechnology, 29(2), 191-207.
  • Kavitha, T., & Yuvaraj, H. (2011). A facile approach to the synthesis of high-quality NiO nanorods: electrochemical and antibacterial properties. Journal of Materials Chemistry, 21(39), 15686-15691.
  • Klasen, H. J. (2000). A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns, 26(2), 131-138.
  • Marabelli, F., Parravicini, G. B., & Salghetti-Drioli, F. (1995). Optical gap of CuO. Physical Review B, 52(3), 1433.
  • Morones, J. R., Elechiguerra, J. L., Camacho, A., Holt, K., Kouri, J. B., Ramírez, J. T., & Yacaman, M. J. (2005). The bactericidal effect of silver nanoparticles. Nanotechnology, 16(10), 2346.
  • Ozin, G. A., & Arsenault, A. (2015). Nanochemistry: a chemical approach to nanomaterials. Royal Society of Chemistry.
  • Pal, C., Asiani, K., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. J., & Hobman, J. L. (2017). Metal resistance and its association with antibiotic resistance. In Advances in microbial physiology (Vol. 70, pp. 261-313). Academic Press.
  • Peymania, M., Ghaedib, K., & Nasr-Esfahanib, M. H. (2015). Review of the Role of PPAR Gamma and Agonists in the Development of Heart. The International Journal of Biotechnology, 4(2), 9-13
  • Pinto, R. J., Marques, P. A., Neto, C. P., Trindade, T., Daina, S., & Sadocco, P. (2009). Antibacterial activity of nanocomposites of silver and bacterial or vegetable cellulosic fibers. Acta Biomaterialia, 5(6), 2279-2289.
  • Quester, K., Avalos-Borja, M., & Castro-Longoria, E. (2013). Biosynthesis and microscopic study of metallic nanoparticles. Micron, 54, 1-27.
  • Shahverdi, A. R., Fakhimi, A., Shahverdi, H. R., & Minaian, S. (2007). Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli. Nanomedicine: Nanotechnology, Biology and Medicine, 3(2), 168-171.
  • Shenashen, M. A., El‐Safty, S. A., & Elshehy, E. A. (2014). Synthesis, morphological control, and properties of silver nanoparticles in potential applications. Particle & Particle Systems Characterization, 31(3), 293-316.
  • Silver, S. (2003). Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS microbiology reviews, 27(2-3), 341-353.
  • Sintubin, L., Verstraete, W., & Boon, N. (2012). Biologically produced nanosilver: current state and future perspectives. Biotechnology and Bioengineering, 109(10), 2422-2436.
  • Stoimenov, P. K., Klinger, R. L., Marchin, G. L., & Klabunde, K. J. (2002). Metal oxide nanoparticles as bactericidal agents. Langmuir, 18(17), 6679-6686.
  • Wang, L., Hu, C., & Shao, L. (2017). The antimicrobial activity of nanoparticles: present situation and prospects for the future. International journal of nanomedicine, 12, 1227.
  • Wayne, P. A. (2010). Clinical and Laboratory Standards Institute, CLSI,(2009). Performance standards for antimicrobial disk susceptibility tests.
  • Wayne, P. A. (2011). Clinical and laboratory standards institute. Performance standards for antimicrobial susceptibility testing.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.