The present research aim to determine the activity of some antifungal nanoparticles against some molds and yeast strains since Nanoparticles are of wide use in medical field as antimicrobial agents and many promised results show that’s it’s could be suitable for human use with low concentration and these includes multiple metal oxides such as yttrium, copper, nickel, zinc, iron and silver that have antimicrobial activity, in this research we test the antifungal activity of some nanoparticles (NPs) against different strains of mold and yeast. Antimicrobial activity of NPs was accomplished by the mean of disk diffusion assay using dilutions of (200, 100, 50, 25, and 12.5) and the MIC and MFC of each isolate is determined.as well as antibiotic discs were acquired in order to compare its antifungal activity within NPs activity,and those antibiotic include Amikacin (AK30), Cefotaxime(CX30), Ciprofloxacin(CPR5), Gentamicin(CN10). The results show that zinc oxide, ferric oxide, cupper oxide, silver and yittrium nanoparticles have no anti-fungal activity against tested fungi, while there was different inhibitory effect of antibiotics against the selected fungal strain and the KCA antibiotic appeared with the highest activity while the FLU appeared with the least activity.so that its concluded that using NPs as an economic alternative anti-fungal medicine especially in treating ectopic infections must be with high concentration since low concentration give no result without taking risk of developing resistant fungal strains as with antibiotics, as well as to use lab animals for most accurate results.

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