An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients
  • Article Type: Research Article
  • Eurasian Journal of Biosciences, 2020 - Volume 14 Issue 1, pp. 71-79
  • Published Online: 28 Feb 2020
  • Article Views: 552 | Article Download: 357
  • Open Access Full Text (PDF)
AMA 10th edition
In-text citation: (1), (2), (3), etc.
Reference: Ismail MM, Alaaraji SFT. An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients. Eurasia J Biosci. 2020;14(1), 71-79.

APA 6th edition
In-text citation: (Ismail & Alaaraji, 2020)
Reference: Ismail, M. M., & Alaaraji, S. F. T. (2020). An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients. Eurasian Journal of Biosciences, 14(1), 71-79.

Chicago
In-text citation: (Ismail and Alaaraji, 2020)
Reference: Ismail, Moslima M., and Shakir F. T. Alaaraji. "An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients". Eurasian Journal of Biosciences 2020 14 no. 1 (2020): 71-79.

Harvard
In-text citation: (Ismail and Alaaraji, 2020)
Reference: Ismail, M. M., and Alaaraji, S. F. T. (2020). An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients. Eurasian Journal of Biosciences, 14(1), pp. 71-79.

MLA
In-text citation: (Ismail and Alaaraji, 2020)
Reference: Ismail, Moslima M. et al. "An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients". Eurasian Journal of Biosciences, vol. 14, no. 1, 2020, pp. 71-79.

Vancouver
In-text citation: (1), (2), (3), etc.
Reference: Ismail MM, Alaaraji SFT. An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients. Eurasia J Biosci. 2020;14(1):71-9.

Abstract

Background: Anti-inflammatory intermediaries like interleukin-37 (IL-37) have a central function in the disease regulation of rheumatoid arthritis (RA). This study was designed to explore the relationship between IL-37, 8-hydroxydeoxyguanosine (8-OHDG) and certain anthropometric measurements in RA patients, and to investigate whether there are any correlations between IL-37 and 8-OHDG. Materials and Methods: The study comprised 60 patients with RA and 24 age- and sex-matched healthy control subjects (HCs). IL-37 and 8-OHDG serum concentrations were estimated by ELISA. The width of waist (W.W), hip (W.H), thorax (W.T) and neck (W.N) were calculated, along with body mass index (BMI) for all subjects. Results: IL-37 and 8-OHDG serum concentrations were significantly greater in patients with RA. Nevertheless, RA patients showed lower levels of high-density lipoprotein (HDL) and hemoglobin (Hb). Elevated serum concentrations of IL-37 were found to be positively associated with waist to hip ratio (W/H), waist to thoracic ratio (W/T), waist to neck ratio (W/N), ESR and Hb, while raised serum concentrations of 8-OHDG were positively related with W/H, W/T, SBP, DBP, creatinine and total cholesterol (TC). IL-37 exhibited the highest ROC curve value in comparison to other studied markers. Conclusion: Both anti-inflammatory cytokine (IL-37) and the marker of DNA impairment (8-OHDG) form part of RA’s pathogenesis. IL-37 and 8-OHDG may be used as possible biomarkers of active RA.

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